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COVID-19 convalescent plasma; time for "goal directed therapy"?

作者信息

Knudson Charles Michael, Jackson J Brooks

机构信息

DeGowin Blood Center, Department of Pathology, University of Iowa Hospitals & Clinics (UIHC), Iowa City, Iowa, USA.

出版信息

Transfusion. 2021 May;61(5):1654-1656. doi: 10.1111/trf.16381. Epub 2021 Mar 26.

DOI:10.1111/trf.16381
PMID:33723852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8250757/
Abstract
摘要

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Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19.恢复期血浆抗体水平与新冠死亡风险。
N Engl J Med. 2021 Mar 18;384(11):1015-1027. doi: 10.1056/NEJMoa2031893. Epub 2021 Jan 13.
2
Temporal Analysis of Serial Donations Reveals Decrease in Neutralizing Capacity and Justifies Revised Qualifying Criteria for Coronavirus Disease 2019 Convalescent Plasma.时间序列分析揭示了新型冠状病毒疾病恢复期血浆中和能力的下降，并证明了修订的资格标准是合理的。
J Infect Dis. 2021 Mar 3;223(5):743-751. doi: 10.1093/infdis/jiaa803.
3
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults.早期高滴度血浆疗法预防老年人重症 COVID-19。
N Engl J Med. 2021 Feb 18;384(7):610-618. doi: 10.1056/NEJMoa2033700. Epub 2021 Jan 6.
4
Safety and efficacy of convalescent plasma therapy in severely and critically ill patients with COVID-19: a systematic review with meta-analysis.COVID-19 重症和危重症患者恢复期血浆治疗的安全性和有效性：系统评价和荟萃分析。
Aging (Albany NY). 2020 Dec 15;13(1):1498-1509. doi: 10.18632/aging.202195.
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Effectiveness of Convalescent Plasma Therapy in the Treatment of Moderate to Severe COVID 19 Patients: A Systematic Review and Meta-Analysis.康复期血浆疗法治疗中重度新型冠状病毒肺炎患者的有效性：一项系统评价与Meta分析
J Assoc Physicians India. 2020 Dec;68(12):35-43.
6
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia.新冠肺炎重症肺炎患者恢复期血浆的随机临床试验。
N Engl J Med. 2021 Feb 18;384(7):619-629. doi: 10.1056/NEJMoa2031304. Epub 2020 Nov 24.
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J Clin Microbiol. 2021 Jan 21;59(2). doi: 10.1128/JCM.02257-20.
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Nat Commun. 2020 Sep 17;11(1):4704. doi: 10.1038/s41467-020-18450-4.
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Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients.血清学检测评估康复的新冠肺炎患者中高度可变的新冠病毒中和抗体活性。
J Clin Microbiol. 2020 Nov 18;58(12). doi: 10.1128/JCM.02005-20.
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Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.性别、年龄和住院情况会影响 COVID-19 恢复期血浆捐献者人群的抗体反应。
J Clin Invest. 2020 Nov 2;130(11):6141-6150. doi: 10.1172/JCI142004.