Oral Health Prev Dent. 2021 Mar 17;19:203-216. doi: 10.3290/j.ohpd.b1075107.
To evaluate the comprehensive effects of photobiomodulation (PBM) therapy on teeth after active orthodontic treatment.
This systematic review was conducted according to the PRISMA guidelines. Six databases were electronically searched and screened for eligible human and animal studies published up to August 2020. The risk of bias was assessed based on the Cochrane Handbook for Systematic Reviews of Interventions and Systematic Review Centre for Laboratory Experiment Tool. Two independent reviewers performed all procedures in duplicate. Any disagreement was resolved by discussion or consultation with a third reviewer.
A total of 395 records were identified from the initial search up to August 2020. Following screening, 16 full-text articles were reviewed for eligibility (κ > 0.90), and ultimately 9 studies (3 clinical studies and 6 animal studies) were included in this review. The key outcomes observed were 'tooth position maintenance' and 'root resorption rehabilitation'. Two controlled clinical trials and two animal studies supported the preventive effects of PBM therapy on the relapse of post-orthodontic tooth positions, while the other two animal studies reported opposing findings. Regarding root resorption, all evidence supported the rehabilitation potential using PBM therapy for teeth that had undergone orthodontic tooth movement. There was a high risk of bias among studies, except for one randomised controlled trial. Due to the substantial heterogeneity among studies in terms of their types, participants, designs, PBM therapy settings and variables of interest, it was not possible to conduct a meta-analysis; therefore, a qualitative synthesis is presented.
The quality of evidence for PBM therapy contributing to the maintenance of tooth position or improved dental health after orthodontic treatment remains low. There is considerable controversy over the effects of PBM therapy on orthodontic relapse. However, the use of PBM therapy after orthodontic treatment has promising effects for root resorption rehabilitation and is generally recommended.
评估光生物调节（PBM）疗法对正畸治疗后牙齿的综合影响。
本系统评价按照 PRISMA 指南进行。电子检索了六个数据库，筛选了截至 2020 年 8 月发表的人类和动物研究。根据 Cochrane 干预系统评价手册和系统评价中心实验室实验工具评估了偏倚风险。两名独立评审员重复进行了所有程序。任何分歧均通过讨论或与第三名评审员协商解决。
从最初的搜索到 2020 年 8 月，共确定了 395 条记录。经过筛选，有 16 篇全文文章符合纳入标准（κ>0.90），最终有 9 项研究（3 项临床研究和 6 项动物研究）纳入本综述。主要观察结果是“牙齿位置维持”和“牙根吸收康复”。两项对照临床试验和两项动物研究支持 PBM 疗法对正畸后牙齿位置复发的预防作用，而另外两项动物研究则报告了相反的结果。关于牙根吸收，所有证据都支持使用 PBM 疗法对接受过正畸牙齿移动的牙齿进行康复。除了一项随机对照试验外，其他研究都存在高偏倚风险。由于研究在类型、参与者、设计、PBM 治疗设置和感兴趣变量方面存在很大的异质性，因此无法进行荟萃分析；因此，本文进行了定性综合。
PBM 疗法在维持正畸治疗后牙齿位置或改善牙齿健康方面的证据质量仍然较低。关于 PBM 疗法对正畸复发的影响存在很大争议。然而，正畸治疗后使用 PBM 疗法对牙根吸收康复有很好的效果，一般建议使用。
