State Scientific Center of the Russian Federation - Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Bull Exp Biol Med. 2021 Feb;170(4):560-564. doi: 10.1007/s10517-021-05106-6. Epub 2021 Mar 16.
Microgravity negatively affects the bone tissue which manifested in a decrease in mineral density of the bones during long-term space flights. Impairments of bone homeostasis are determined among other things by changes in secretory activity of heterogeneous populations of low-committed precursors, such as mesenchymal stromal cells (MSC) and osteoblasts. We studied the effect of microgravity modeling during 10 days on paracrine activity of osteogenically committed and intact MSC. Cell response to simulated microgravity depended on the degree of commitment. The response of osteogenically committed MSC was less pronounced and manifested in increased production of sclerostin. In intact MSC, an increase in IL-8 and VEGF secretion and a decrease in osteoprotegerin level were detected. These changes can underlie the shift of bone homeostasis towards bone resorption.
微重力会对骨骼组织产生负面影响，在长期的太空飞行中，会导致骨骼矿物质密度降低。骨骼内稳态的损伤除其他因素外，还取决于低分化前体细胞（如间充质基质细胞[MSC]和成骨细胞）分泌活性的变化。我们研究了 10 天模拟微重力对成骨定向和完整 MSC 旁分泌活性的影响。细胞对模拟微重力的反应取决于定向程度。成骨定向 MSC 的反应不那么明显，表现为骨硬化蛋白的产生增加。在完整的 MSC 中，检测到 IL-8 和 VEGF 分泌增加，骨保护素水平降低。这些变化可能是骨骼内稳态向骨吸收转移的基础。
