特定的谵妄病因与死亡有不同的关联吗？一项住院患者的纵向队列研究。
Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients.
机构信息
Department of Population Science and Experimental Medicine, MRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Department of Medicine, Dalhousie University, Halifax, NS, Canada.
出版信息
Eur Geriatr Med. 2021 Aug;12(4):787-791. doi: 10.1007/s41999-021-00474-8. Epub 2021 Mar 16.
PURPOSE
To describe aetiology-specific associations with mortality among older hospital patients with delirium.
METHODS
Over 21 months, a cohort of 1702 patients with 2471 acute hospital admissions (median age 85, IQR 80-90, 56% women) were assessed for delirium, categorised with inflammatory and metabolic aetiologies based on available laboratory results, and followed up for all-cause mortality. Interactions between aetiology and delirium were tested.
RESULTS
The total mortality for the cohort was 35.2%. While inflammation, metabolic disturbance, and delirium at time of admission all demonstrated independent associations with mortality, there was no evidence for any interactions between delirium and these laboratory-measured aetiologies.
CONCLUSIONS
Delirium remains an important predictor of death in older hospital patients, irrespective of underlying aetiology.
目的
描述老年住院患者谵妄与死亡率之间的病因特异性关联。
方法
在 21 个月的时间里，对 1702 名患有谵妄的患者进行了队列研究，这些患者有 2471 次急性住院治疗（中位年龄 85 岁，IQR 80-90 岁，56%为女性），根据可用的实验室结果将其病因归类为炎症性和代谢性病因，并对所有原因的死亡率进行了随访。对病因和谵妄之间的相互作用进行了检验。
结果
该队列的总死亡率为 35.2%。虽然炎症、代谢紊乱以及入院时的谵妄均与死亡率有独立关联，但在谵妄与这些实验室检测病因之间没有证据表明存在任何相互作用。
结论
无论潜在病因如何，谵妄仍然是老年住院患者死亡的重要预测因素。
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