Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Int Immunopharmacol. 2021 Jun;95:107528. doi: 10.1016/j.intimp.2021.107528. Epub 2021 Mar 13.
Interleukin (IL)-38 is the tenth member of the IL-1 cytokine family. IL-38 shares high similarity with IL-36Ra and IL-1Ra and can bind to their receptors, thus exerting an anti-inflammatory effect. Despite the lack of a signal peptide, IL-38 can be released from several cell types, but its maturation process remains obscure. The role of IL-38 in numerous inflammatory diseases, especially in autoimmune diseases, has been extensively studied. In this review, we discuss the characteristics, biological functions and pathways of IL-38, as well as its role in several chronic inflammatory diseases. Better understanding the role of IL-38 will pave the way for clinical treatments in the near future.
白细胞介素 (IL)-38 是白细胞介素 1 细胞因子家族的第十个成员。IL-38 与 IL-36Ra 和 IL-1Ra 具有高度相似性，可以与它们的受体结合，从而发挥抗炎作用。尽管缺乏信号肽，IL-38 仍可以从几种细胞类型中释放出来，但它的成熟过程仍不清楚。IL-38 在许多炎症性疾病中，特别是在自身免疫性疾病中的作用已被广泛研究。在这篇综述中，我们讨论了 IL-38 的特征、生物学功能和途径，以及它在几种慢性炎症性疾病中的作用。更好地了解 IL-38 的作用将为未来的临床治疗铺平道路。
