儿童获得难治性肺炎支原体肺炎的危险因素：一项荟萃分析。

The risk factors of children acquiring refractory mycoplasma pneumoniae pneumonia: A meta-analysis.

机构信息

Department of Pediatrics, Shenyang Fifth People's Hospital.

Department of Infectious Disease, Shenyang Center for Disease Control and Prevention.

出版信息

Medicine (Baltimore). 2021 Mar 19;100(11):e24894. doi: 10.1097/MD.0000000000024894.

DOI:10.1097/MD.0000000000024894

PMID:33725960

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7982158/

Abstract

OBJECTIVES

Refractory mycoplasma pneumoniae pneumonia (RMPP) in children has been increasing worldwide. In this study, we conducted a meta-analysis to generate large-scale evidence on the risk factors of RMPP to provide suggestions on prevention and controlling for children.

METHODS

Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang (Chinese) were searched to identify relevant articles. All analyses were performed using Stata 14.0.

RESULTS

We conducted a meta-analysis of 15 separate studies. Fever for more than 10 days (odds ratio [OR] 3.965, 95% confidence interval [CI] 2.109-7.456), pleural effusion (OR 6.922, 95% CI 2.058-23.282), extra-pulmonary complications (OR 17.762, 95% CI 11.146-28.305), pulmonary X-ray consolidation ≥2/3 (OR 8.245, 95% CI 1.990-34.153), CRP >40 mg/L (OR 4.975, 95% CI 2.116-11.697) were significantly related to the risk of RMPP. We did not find an association between male sex (OR 0.808, 95% CI 0.548-1.189), LDH >410IU/L (OR 1.033, 95% CI 0.979-1.091) and the risk of RMPP.

CONCLUSIONS

Fever for more than 10 days, pleural effusion, extra-pulmonary complications, pulmonary X-ray consolidation≥ 2/3 and CRP >40 mg/L are risk factors for early evaluation of RMPP.

摘要

目的

全球范围内儿童难治性肺炎支原体肺炎（RMPP）的发病率不断上升。本研究通过荟萃分析，旨在为儿童 RMPP 的防治提供建议，生成大规模的 RMPP 危险因素证据。

方法

检索 Web of Science、PubMed、Embase、Cochrane Library、中国知网和万方（中文）数据库，以确定相关文献。所有分析均使用 Stata 14.0 进行。

结果

本研究共纳入 15 项独立研究进行荟萃分析。发热超过 10 天（比值比[OR] 3.965，95%置信区间[CI] 2.109-7.456）、胸腔积液（OR 6.922，95% CI 2.058-23.282）、肺外并发症（OR 17.762，95% CI 11.146-28.305）、肺部 X 线实变≥2/3（OR 8.245，95% CI 1.990-34.153）、C 反应蛋白（CRP）>40mg/L（OR 4.975，95% CI 2.116-11.697）与 RMPP 风险显著相关。未发现男性（OR 0.808，95% CI 0.548-1.189）、乳酸脱氢酶（LDH）>410IU/L（OR 1.033，95% CI 0.979-1.091）与 RMPP 风险相关。