Department of Surgery, National Hospital Organization, Tsuruga Medical Center, 33-1, Sakuragaoka, Tsuruga, Fukui, 914-0195, Japan.
Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University, 4-1-1 Kenjojima, Matsuoka, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.
World J Surg Oncol. 2021 Mar 16;19(1):79. doi: 10.1186/s12957-021-02177-7.
Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient's long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis.
The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.
胰腺肉瘤样癌（SCP）是一种极其罕见且侵袭性强、预后差的疾病。我们已经报道了一例罕见的 SCP 长期生存病例。在本文中，我们从细胞衰老的角度研究了患者长期生存的潜在机制，通过免疫组织化学分析，对包括我们报道的病例在内的三例 SCP 进行了研究。
在长期生存患者的肉瘤成分中观察到细胞衰老标志物的表达，但在短期生存的其他患者中未观察到。因此，我们可以推测细胞衰老可能在降低肉瘤细胞的增殖和转移活性方面发挥重要作用，从而导致患者的长期生存。
