Department of Periodontology, Medical University of Lublin, Lublin, Poland.
Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.
BMC Oral Health. 2021 Mar 16;21(1):120. doi: 10.1186/s12903-021-01478-3.
Our study aimed to assess the level of IL-1β, CXCL8, and TNF-α in peri-implant sulcular fluid (PISF) collected from patients with no clinical symptoms of mucositis or peri-implantitis and compare them with cytokine concentration in gingival crevicular fluid (GCF) acquired from patients with healthy periodontium and those with varying severity of periodontitis.
A total of 189 subjects were included in the study, and GCF/PISF samples were checked for IL-1β, CXCL8, and TNF-α levels using an ELISA test.
The IL-1β level in PISF in patients with implants was significantly lower than in GCF in patients with mild, moderate, or severe periodontitis. The CXCL8 level in PISF was considerably lower than in patients with moderate periodontitis. The TNF-α level in PISF in patients with implants was markedly higher compared to subjects with healthy periodontium or patients with mild periodontitis.
Analysis of cytokine levels may help describe the pathogenesis and early diagnosis of peri-implantitis and prevision in high-risk patients.
本研究旨在评估无黏膜炎或种植体周围炎临床症状患者的种植体周围龈沟液（PISF）中白细胞介素 1β（IL-1β）、趋化因子（CXCL）8 和肿瘤坏死因子-α（TNF-α）的水平，并将其与健康牙周和不同严重程度牙周炎患者的龈沟液（GCF）中的细胞因子浓度进行比较。
本研究共纳入 189 名受试者，采用 ELISA 试验检测 GCF/PISF 样本中 IL-1β、CXCL8 和 TNF-α 的水平。
种植体患者 PISF 中的 IL-1β 水平明显低于轻度、中度或重度牙周炎患者的 GCF。PISF 中的 CXCL8 水平明显低于中度牙周炎患者。种植体患者 PISF 中的 TNF-α 水平明显高于健康牙周和轻度牙周炎患者。
细胞因子水平分析可能有助于描述种植体周围炎的发病机制和早期诊断，并对高危患者进行预测。
