Lima Bezerra José Jailson, Vieira Pinheiro Anderson Angel, Barbosa Lucena Ricardo
Universidade Federal de Pernambuco, Departamento de Botânica, Av. da Engenharia, S/n, Cidade Universitária, 50670-420, Recife, PE, Brazil.
Universidade Federal da Paraíba, Instituto de Pesquisa Em Fármacos e Medicamentos - IpeFarM, Cidade Universitária, 58051-970, João Pessoa, PB, Brazil.
Toxicon. 2021 May;195:78-85. doi: 10.1016/j.toxicon.2021.03.010. Epub 2021 Mar 13.
Mimosa tenuiflora (Willd.) Poir. (Fabaceae) is a plant native to Brazil and occurs in the phytogeographic domains of Caatinga and Cerrado. Relevant studies have investigated the chemical components of this plant and others have already demonstrated its teratogenic potential. It has been proven that this plant causes congenital malformations in farm animals and, consequently, financial losses to farmers in the Brazilian semiarid region. The present work aimed to carry out a bibliographic survey on the teratogenic effects of M. tenuiflora in ruminants and to group the chemical compounds occurring in this species. For this, databases were consulted and twenty-four articles published in the last 30 years (1990-2020) were included. According to the scientific documents analyzed, M. tenuiflora has embryotoxic, fetotoxic and abortive potential in farm animals, especially sheep and goats. The main classes of chemical compounds present in this species are alkaloids, saponins, flavonoids, and terpenoids. It is likely that some of these substances, mainly the indole alkaloid N,N-dimethyltryptamine, are related to the teratogenic effects reported in ruminants in the Brazilian semiarid region.
含羞草（Mimosa tenuiflora (Willd.) Poir.，豆科）是一种原产于巴西的植物，生长在卡廷加和塞拉多植物地理区域。相关研究已对该植物的化学成分进行了调查，其他研究也已证明其致畸潜力。事实证明，这种植物会导致农场动物出现先天性畸形，从而给巴西半干旱地区的农民造成经济损失。本研究旨在对含羞草对反刍动物的致畸作用进行文献综述，并对该物种中存在的化合物进行分类。为此，查阅了数据库，并纳入了过去30年（1990 - 2020年）发表的24篇文章。根据分析的科学文献，含羞草对农场动物，尤其是绵羊和山羊具有胚胎毒性、胎儿毒性和流产潜力。该物种中存在的主要化合物类别是生物碱、皂苷、黄酮类化合物和萜类化合物。这些物质中的一些，主要是吲哚生物碱N,N - 二甲基色胺，可能与巴西半干旱地区反刍动物中报道的致畸作用有关。
