Safdar Afifa, Azman Khairunnuur Fairuz, Zakaria Rahimah, Ab Aziz Che Badariah, Rashid Usman
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
School of Dental Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
J Tradit Complement Med. 2020 Feb 17;11(2):117-122. doi: 10.1016/j.jtcme.2020.02.005. eCollection 2021 Mar.
Goat milk is a food of high nutritional value and has been proved to possess strong antioxidant and anti-inflammatory properties. However, thus far, little is known of its possible effects on brain especially on memory during aging. The aim of this study was to assess the effect of goat milk supplementation on memory in d-galactose-induced aging rat model.
Fifty-two male Sprague Dawley rats were randomly divided into four groups: 1) control group, 2) goat milk treated group, 3) d-galactose treated group, and 4) goat milk plus d-galactose treated group. Goat milk (1 g/kg orally) and/or d-galactose (120 mg/kg subcutaneously) were administered continuously for six weeks preceded and followed by novel object recognition and T-maze test.
Prior to goat milk and d-galactose administration, there was no significant difference ( > 0.05) in memory between all groups. Goat milk administration alone significantly increased short- and long-term memory ( < 0.05) while d-galactose administration alone significantly decreased short-, long-term and spatial memory ( < 0.001). Goat milk treatment to d-galactose-induced rats managed to protect against memory decline as exhibited by significantly higher short-, long-term and spatial memory ( < 0.0001) when compared to the untreated d-galactose-induced rats. These results suggest that goat milk as a whole or due to the taurine or sialic acid contained in goat milk is effective in improving memory functions and may be useful in protecting against age-related memory deficits.
羊奶是一种具有高营养价值的食物，已被证明具有强大的抗氧化和抗炎特性。然而，迄今为止，人们对其对大脑尤其是衰老过程中记忆力的可能影响知之甚少。本研究的目的是评估补充羊奶对d - 半乳糖诱导的衰老大鼠模型记忆力的影响。
52只雄性Sprague Dawley大鼠被随机分为四组：1）对照组，2）羊奶处理组，3）d - 半乳糖处理组，4）羊奶加d - 半乳糖处理组。在进行新物体识别和T迷宫测试之前和之后，连续六周口服给予羊奶（1 g/kg）和/或皮下注射给予d - 半乳糖（120 mg/kg）。
在给予羊奶和d - 半乳糖之前，所有组之间的记忆力没有显著差异（P > 0.05）。单独给予羊奶显著提高了短期和长期记忆力（P < 0.05），而单独给予d - 半乳糖则显著降低了短期、长期和空间记忆力（P < 0.001）。与未处理的d - 半乳糖诱导的大鼠相比，对d - 半乳糖诱导的大鼠进行羊奶处理能够防止记忆力下降，表现为短期、长期和空间记忆力显著更高（P < 0.0001）。这些结果表明，羊奶整体或因其所含的牛磺酸或唾液酸，在改善记忆功能方面是有效的，并且可能有助于预防与年龄相关的记忆缺陷。
