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血浆 D2 型 resolvin 与白三烯 B 比值降低与糖尿病并发缺血性脑卒中患者的预后相关。

Plasma Resolvin D2 to Leukotriene B Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis.

机构信息

Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

出版信息

Biomed Res Int. 2021 Feb 26;2021:6657646. doi: 10.1155/2021/6657646. eCollection 2021.

DOI:10.1155/2021/6657646
PMID:33728336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7935571/
Abstract

BACKGROUND

Diabetes mellitus (DM) aggravates symptoms and prognosis of acute ischemic stroke (AIS), and inflammation plays an important role therein. Resolvin D2 (RvD2) is one of the specialized pro-resolving mediators (SPMs), while leukotriene B (LTB) is a classic proinflammatory mediator. The ratio of RvD2 to LTB is an index of pro-resolving/proinflammatory balance. We aim to explore the role of RvD2/LTB ratio in ischemic stroke complicated with DM.

METHODS

The plasma levels of RvD2 and LTB were analyzed by enzyme immunoassay in stroke patients with DM (DM + AIS group) or without DM (nonDM+AIS group). Patients were followed up at 90 days after stroke onset, and modified Rankin Score (mRS) was assessed. The association of RvD2/LTB ratio with stroke severity and prognosis was also analyzed.

RESULTS

The plasma levels of RvD2 were positively correlated to LTB. The RvD2/LTB ratio in DM + AIS group was lower than that in the nonDM+AIS group. No correlation was found between the RvD2/LTB ratio and infarct size or NIHSS score. The RvD2/LTB ratio at baseline was significantly lower in the poor prognosis group (mRS ≥ 3) than that in the good prognosis group (mRS ≤ 2).

CONCLUSIONS

Our study indicated that the balance between pro-resolving and proinflammatory mediators was impaired by diabetes in ischemic stroke. The RvD2/LTB ratio may serve as a biomarker of prognosis for ischemic stroke.

摘要

背景

糖尿病（DM）可加重急性缺血性脑卒中（AIS）的症状和预后，炎症在此过程中发挥重要作用。消退素 D2（RvD2）是一种特异性的促解决介质（SPM），而白三烯 B（LTB）是一种经典的促炎介质。RvD2/LTB 的比值是促解决/促炎平衡的一个指标。我们旨在探讨 RvD2/LTB 比值在缺血性脑卒中合并 DM 中的作用。

方法

通过酶联免疫吸附法分析 DM 合并 AIS 患者（DM+AIS 组）或不合并 DM 的 AIS 患者（非 DM+AIS 组）的血浆 RvD2 和 LTB 水平。患者在脑卒中发病后 90 天进行随访，采用改良 Rankin 量表（mRS）进行评估。还分析了 RvD2/LTB 比值与脑卒中严重程度和预后的关系。

结果

RvD2 水平与 LTB 呈正相关。DM+AIS 组的 RvD2/LTB 比值低于非 DM+AIS 组。RvD2/LTB 比值与梗死灶大小或 NIHSS 评分无相关性。基线时，预后不良组（mRS≥3）的 RvD2/LTB 比值明显低于预后良好组（mRS≤2）。

结论

本研究表明，糖尿病可使缺血性脑卒中促解决和促炎介质之间的平衡失调。RvD2/LTB 比值可能是缺血性脑卒中预后的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/5da2ecb68b0d/BMRI2021-6657646.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/f6e50f2b0cdf/BMRI2021-6657646.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/52030a950220/BMRI2021-6657646.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/5da2ecb68b0d/BMRI2021-6657646.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/f6e50f2b0cdf/BMRI2021-6657646.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/52030a950220/BMRI2021-6657646.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e29/7935571/5da2ecb68b0d/BMRI2021-6657646.003.jpg

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