在加纳一家综合医院，半乳糖凝集素-3与糖尿病和非糖尿病患者的疟疾相关胰岛素抵抗无关。
Galectin-3 did not associate with malaria-related insulin resistance in diabetic and non-diabetic respondents at a Ghanaian General Hospital.
作者信息
Nortey Emmanuel, Derkyi-Kwarteng Leonard, Amoako-Sakyi Daniel, Bockarie Ansumana Sandy, Yeboah Samuel, Acquah Samuel
机构信息
Department of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Department of Pathology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
出版信息
PLoS One. 2025 Aug 13;20(8):e0330068. doi: 10.1371/journal.pone.0330068. eCollection 2025.
BACKGROUND
Malaria remains endemic in the sub-Saharan African region. The region also faces the world's highest increase in incidence of type 2 diabetes mellitus (T2DM). Although galectin-3 has been explored in numerous conditions, scientific information on the relationship between malaria-related insulin resistance and circulating galectin-3 levels is limited. Therefore, the current study examined the association between galectin-3 and insulin resistance in diabetic and non-diabetic adults with or without malaria at the Tema General Hospital.
METHODS
Anthropometric indices, blood pressure, glucose, full blood count (FBC), lipid profile, insulin and galectin-3 levels were measured under fasting conditions. Insulin resistance and beta-cell function were assessed using the homeostatic model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) formulae.
RESULTS
Participants with T2DM were older (P < 0.05) with higher levels of systolic blood pressure and glucose but lower parasite levels than their non-diabetic counterparts. Irrespective of diabetes status, levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and galectin-3 were higher but triglyceride level was lower in participants with malaria. Levels of insulin, HOMA-B and HOMA-IR were highest for diabetics without malaria with high strengths of the associations. Galectin-3 could neither predict HOMA-B nor HOMA-IR in any of the study groups. Irrespective of malaria or diabetes status, insulin resistance associated with glucose (B = 0.603, Wald = 10.52, Exp (B) = 1.83, CI: 1.27-2.63; P = 0.001) and insulin (B = 1.145, Wald = 18.61, Exp (B) = 3.14, CI: 1.87-5.23; P < 0.001) levels in our context with the model explaining 67.7% (Cox & Snell R2 = 0.677) to 91% (Nagelkerke R2 = 0.91) of the observed variation.
CONCLUSION
The relationship of galectin-3 with HOMA-IR and HOMA-B appears more complex than a linear fashion in our setting.
背景
疟疾在撒哈拉以南非洲地区仍然流行。该地区还面临着世界上2型糖尿病（T2DM）发病率最高的增长情况。尽管半乳糖凝集素-3已在众多疾病中得到研究，但关于疟疾相关胰岛素抵抗与循环半乳糖凝集素-3水平之间关系的科学信息有限。因此，本研究在特马综合医院对患有或未患有疟疾的糖尿病和非糖尿病成年人中半乳糖凝集素-3与胰岛素抵抗之间的关联进行了研究。
方法
在空腹条件下测量人体测量指标、血压、血糖、全血细胞计数（FBC）、血脂谱、胰岛素和半乳糖凝集素-3水平。使用胰岛素抵抗稳态模型评估（HOMA-IR）和β细胞功能（HOMA-B）公式评估胰岛素抵抗和β细胞功能。
结果
与非糖尿病参与者相比，T2DM参与者年龄更大（P < 0.05），收缩压和血糖水平更高，但寄生虫水平更低。无论糖尿病状态如何，患有疟疾的参与者总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和半乳糖凝集素-3水平更高，但甘油三酯水平更低。胰岛素、HOMA-B和HOMA-IR水平在无疟疾的糖尿病患者中最高，且关联强度较高。在任何研究组中，半乳糖凝集素-3既不能预测HOMA-B也不能预测HOMA-IR。无论疟疾或糖尿病状态如何，在我们的研究中，胰岛素抵抗与血糖（B = 0.603，Wald = 10.52，Exp (B) = 1.83，CI：1.27 - 2.63；P = 0.001）和胰岛素（B = 1.145，Wald = 18.61，Exp (B) = 3.14，CI：1.87 - 5.23；P < 0.001）水平相关，模型解释了观察到的变异的67.7%（Cox & Snell R2 = 0.677）至91%（Nagelkerke R2 = 0.91）。
结论
在我们的研究环境中，半乳糖凝集素-3与HOMA-IR和HOMA-B的关系似乎比线性关系更为复杂。
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