Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-University Erlangen/Nürnberg, Erlangen, Germany.
Department of Dermatology, University Hospital of Puerto Real, Cádiz, Spain.
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1516-1525. doi: 10.1111/jdv.14423. Epub 2017 Aug 13.
Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, such as introduction of new substances, new products or formulations and regulatory intervention, the spectrum of contact sensitization changes.
To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe.
Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (ESSCA, www.essca-dc.org) in consecutively patch-tested patients, 2013/14, in 46 departments in 12 European countries.
Altogether, 31 689 patients were included in the analysis. Compared to a similar analysis in 2004, the prevalence of contact allergy to methylisothiazolinone went up to around 20% in several departments. In comparison, contact allergy to the metals nickel, cobalt and chromium remained largely stable, at 18.1%, 5.9% and 3.2%, respectively, similar to mostly unchanged prevalence with fragrance mix I, II and Myroxylon pereirae (balsam of Peru) at 7.3%, 3.8% and 5.3%, respectively. In the subgroup of departments diagnosing (mainly) patients with occupational contact dermatitis, the prevalence of work-related contact allergies such as epoxy resin or rubber additives was found to be increased, compared to general dermatology departments.
Continuous surveillance of contact allergy based on network data offers the identification of time trends or persisting problems, and thus enables focussing in-depth research (subgroup analyses, exposure analysis) on areas where it is needed.
接触过敏是一种常见病症，可能严重干扰日常生活或职业活动。由于接触物（如新物质、新产品或配方的引入，以及监管干预）的变化，接触致敏的范围也在发生变化。
评估欧洲基本系列过敏原（EBS）中接触致敏物在整个欧洲的现状。
回顾性分析 2013/14 年欧洲接触过敏监测系统（ESSCA，www.essca-dc.org）在 12 个欧洲国家的 46 个部门连续斑贴试验患者的数据。
共纳入 31689 例患者进行分析。与 2004 年的类似分析相比，几种制剂中甲基异噻唑啉酮的接触过敏率上升到 20%左右。相比之下，金属镍、钴和铬的接触过敏率基本保持稳定，分别为 18.1%、5.9%和 3.2%，与香料混合物 I、II 和秘鲁香脂（秘鲁香膏）的基本不变的流行率相似，分别为 7.3%、3.8%和 5.3%。在诊断（主要）职业性接触性皮炎患者的部门亚组中，与普通皮肤科部门相比，发现环氧树脂或橡胶添加剂等职业性接触过敏的患病率有所增加。
基于网络数据的接触过敏连续监测可识别时间趋势或持续存在的问题，从而能够针对需要的领域进行深入研究（亚组分析、暴露分析）。
