Burkhard Lawrence P, Lahren Tylor J, Highland Terry L, Hockett James R, Mount David R, Norberg-King Teresa J
Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure (CCTE), Office of Research and Development, U.S. Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN, 55804, USA.
Arch Environ Contam Toxicol. 2021 Apr;80(3):579-586. doi: 10.1007/s00244-021-00824-4. Epub 2021 Mar 17.
The brominated flame retardant bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBPH) is used widely in consumer items including polyurethane foam used in furniture. Information on its bioaccumulation in aquatic species is limited. In the current study, sediment bioaccumulation tests with the oligochaete Lumbriculus variegatus were performed on a spiked natural sediment equilibrated for 14.5 months. Analysis showed the TBPH used to spike the sediment contained a small amount (0.046% by mass) of mono-(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBMEHP), a potential biotransformation product of the parent chemical. Steady-state biota-sediment accumulation factors (BSAFs) of 0.254 and 1.50 (kg organic carbon/kg lipid) were derived for TBPH and TBMEHP, respectively. TBPH had biphasic elimination behavior where 94% of the body burden was depleted within the first 12 h of elimination (i.e., half-life of 1.2 h or less) and the remaining 6% eliminated very slowly thereafter (half-life of 15 days). There was little evidence for biotransformation of either chemical by L. variegatus. This investigation confirms the extremely hydrophobic behavior of TBPH and its impact on its bioavailability.
溴化阻燃剂双（2-乙基己基）-3,4,5,6-四溴邻苯二甲酸酯（TBPH）广泛用于消费品中，包括家具中使用的聚氨酯泡沫。关于其在水生物种中生物累积的信息有限。在当前研究中，对一种经过14.5个月平衡的加标天然沉积物进行了寡毛纲颤蚓的沉积物生物累积试验。分析表明，用于加标沉积物的TBPH含有少量（质量分数0.046%）的单（2-乙基己基）-3,4,5,6-四溴邻苯二甲酸酯（TBMEHP），这是母体化学品的一种潜在生物转化产物。TBPH和TBMEHP的稳态生物群-沉积物累积因子（BSAFs）分别为0.254和1.50（kg有机碳/kg脂质）。TBPH具有双相消除行为，其中94%的体内负荷在消除的前12小时内耗尽（即半衰期为1.2小时或更短），此后剩余的6%消除非常缓慢（半衰期为15天）。几乎没有证据表明颤蚓对这两种化学品进行了生物转化。这项研究证实了TBPH的极强疏水性及其对其生物利用度的影响。
