Mickelsen P A, Viano-Paulson M C, Stevens D A, Diaz P S
Clinical Microbiology Laboratory, Stanford University Hospital, California.
J Infect Dis. 1988 Jun;157(6):1163-8. doi: 10.1093/infdis/157.6.1163.
Malassezia pachydermatis, a yeast that has not previously been implicated as a cause of human disease, was isolated from cultures of blood from three infants. All infants were 25-27 w of gestational age and had multiple underlying medical problems. The infants had been hospitalized for at least six weeks, had received broad-spectrum antibiotics, and had received parenteral lipid nutrition via a central venous catheter. In one patient, fungemia was accompanied by clinical and laboratory evidence of Broviac catheter infection. During a three-year period, M. pachydermatis was also recovered from fungal cultures of an additional 30 patients, 85% of whom were infants. A pathogenic role for M. pachydermatis recovered from sources other than blood or catheters was not established. Risk factors for and symptoms in infants with M. pachydermatis fungemia appeared to be similar to those described for Malassezia furfur sepsis.
厚皮马拉色菌是一种以前未被认为是人类疾病病因的酵母菌，从三名婴儿的血培养物中分离得到。所有婴儿的胎龄均为25 - 27周，且有多种潜在的医学问题。这些婴儿已住院至少六周，接受了广谱抗生素治疗，并通过中心静脉导管接受肠外脂质营养。在一名患者中，真菌血症伴有Broviac导管感染的临床和实验室证据。在三年期间，还从另外30名患者的真菌培养物中分离出厚皮马拉色菌，其中85%为婴儿。从血液或导管以外的来源分离出的厚皮马拉色菌的致病作用尚未确定。患有厚皮马拉色菌真菌血症的婴儿的危险因素和症状似乎与糠秕马拉色菌败血症所描述的相似。
