Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, Engineering Center of Jiangxi University for Fine Chemicals, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, People's Republic of China.
Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Science, Jiangxi Agricultural University, Nanchang 330045, People's Republic of China.
Nanotechnology. 2021 Apr 6;32(26). doi: 10.1088/1361-6528/abef94.
Herein, TiCTMXene/N-doped reduced graphene oxide (MXene/N-rGO) composite was employed as the electrocatalyst to construct a new electrochemical sensing platform for the determination of adrenaline (AD). The MXene/N-rGO was synthesized via a facile one-step hydrothermal method, where ethylenediamine acted as a reducing agent and N source. The doped N in rGO served as a bridge between MXene and rGO through tight hydrogen bonds. Scanning electron microscopy showed that large numbers of MXenes with accordion-like morphology were distributed on the surface of the N-rGO. The MXene/N-rGO composite displayed a synergetic catalytic effect for oxidizing AD, originating from the unique catalytic activity of N-rGO and the large surface area and satisfactory conductivity of MXene. These characteristics of composite material led to a remarkable effect on signal amplification for the detection of AD, with a wide linear range from 10.0 nM to 90.0M and a low detection limit of 3.0 nM based on a signal to noise ratio of 3. Moreover, the MXene/N-rGO electrode displayed good stability, repeatability, and reproducibility. Additionally, the proposed sensor was successfully applied for voltammetric sensing of AD in urine with recoveries from 97.75% to 103.0%.
在此，采用 TiCTMXene/N 掺杂还原氧化石墨烯（MXene/N-rGO）复合材料作为电催化剂，构建了一种新的电化学传感平台，用于测定肾上腺素（AD）。MXene/N-rGO 通过简便的一步水热法合成，其中乙二胺作为还原剂和 N 源。rGO 中的掺杂 N 通过紧密氢键在 MXene 和 rGO 之间充当桥梁。扫描电子显微镜表明，大量具有手风琴状形貌的 MXenes 分布在 N-rGO 的表面上。MXene/N-rGO 复合材料对 AD 的氧化表现出协同催化作用，源于 N-rGO 的独特催化活性以及 MXene 的大表面积和令人满意的导电性。这种复合材料的特性对 AD 的检测信号放大产生了显著的效果，具有从 10.0 nM 到 90.0M 的宽线性范围和基于 3 的信噪比的低检测限 3.0 nM。此外，MXene/N-rGO 电极表现出良好的稳定性、重复性和重现性。此外，该传感器成功应用于尿液中 AD 的伏安传感，回收率为 97.75%至 103.0%。
