LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany.
Department of Woman and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research Leipzig (CPL), Leipzig University, Leipzig, Germany.
Horm Res Paediatr. 2020;93(9-10):548-557. doi: 10.1159/000513787. Epub 2021 Mar 17.
Current health literature suggests that there has been a decline in the age of pubertal onset and that pubertal onset/duration of puberty may, besides weight status, be influenced by socioeconomic context.
The goal of this study was to determine whether pubertal onset/duration and puberty-triggering hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) vary according to socioeconomic status (SES). Moreover, we aimed to propose cutoff values of serum LH and FSH for predicting gonadarche in boys.
2,657 apparently healthy children and adolescents between 5.5 and 18 years from the area of Leipzig were recruited from the LIFE Child study. Age at pubertal onset/end of puberty was given in 738/573 children, respectively. Anthropometric parameters of puberty, blood measurements of LH and FSH, and questionnaires assessing SES were evaluated.
Lower SES was associated with earlier thelarche and longer duration of puberty in overweight/obese girls, whereas age of menarche was not affected. In boys with low SES, a trend versus earlier puberty onset can be seen. Lower SES was significantly associated with boys' age at mutation. No significant differences in boys' and girls' serum levels of LH and FSH during puberty according to SES were observed. Serum LH levels of 0.56 IU/L and serum FSH levels of 1.74 IU/L showed the best prediction of gonadarche in boys.
Puberty onset/duration and boys' age at mutation is affected by SES. The proposed cutoff levels for serum LH and FSH could provide a serological tool to determine gonadarche in boys.
目前的健康文献表明，青春期开始的年龄有所下降，除了体重状况外，青春期开始/持续时间可能还受到社会经济背景的影响。
本研究的目的是确定青春期开始/持续时间和青春期触发激素促黄体生成素（LH）和卵泡刺激素（FSH）是否根据社会经济地位（SES）而有所不同。此外，我们旨在提出血清 LH 和 FSH 的截断值，以预测男孩的性腺启动。
从莱比锡地区 LIFE Child 研究中招募了 2657 名年龄在 5.5 至 18 岁之间的明显健康的儿童和青少年。分别在 738/573 名儿童中给出了青春期开始/结束的年龄。评估了青春期的人体测量参数、LH 和 FSH 的血液测量值以及评估 SES 的问卷。
较低的 SES 与超重/肥胖女孩的初潮较早和青春期持续时间较长相关，而初潮年龄不受影响。在 SES 较低的男孩中，可以看到青春期开始较早的趋势。SES 较低与男孩的突变年龄显著相关。根据 SES，在青春期男孩和女孩的血清 LH 和 FSH 水平没有观察到显著差异。血清 LH 水平为 0.56IU/L 和血清 FSH 水平为 1.74IU/L 对男孩的性腺启动具有最佳的预测效果。
青春期开始/持续时间和男孩的突变年龄受到 SES 的影响。建议的血清 LH 和 FSH 截断值可以提供一种血清学工具，用于确定男孩的性腺启动。
