Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.
Norwegian Centre for Mental Disorders Research, University of Oslo and Oslo University Hospital, Oslo, Norway.
Nat Commun. 2023 Oct 23;14(1):6698. doi: 10.1038/s41467-023-41839-w.
Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This complexity poses a dimensionality problem when attempting to chart an individual's brain development over time. Here, we illustrate that shifts in subject similarity of brain imaging data relate to pubertal maturation in the longitudinal ABCD study. Given that puberty depicts a critical window for emerging mental health issues, we additionally show that our model is capable of capturing variance in the adolescent brain related to psychopathology in a population-based and a clinical cohort. These results suggest that low-dimensional reference spaces based on subject similarities render useful to chart variance in brain development in youths.
青春期标志着大脑动态的深刻变化，协调了大量神经影像学衍生表型的变化。当试图绘制个体大脑随时间的发育时，这种复杂性构成了一个维度问题。在这里，我们说明了脑成像数据中主体相似性的变化与 ABCD 纵向研究中的青春期成熟有关。鉴于青春期是出现心理健康问题的关键时期，我们还表明，我们的模型能够捕捉到基于人群和临床队列的青少年大脑中与精神病理学相关的变异性。这些结果表明，基于主体相似性的低维参考空间有助于绘制青少年大脑发育的变异性。
