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急诊科急性大麻中毒:合法化的影响。

Acute cannabis intoxication in the emergency department: the effect of legalization.

机构信息

St. Joseph's Healthcare Hamilton, Emergency Department, 50 Charlton Ave E, Hamilton, ON, L8N 4A6, Canada.

Department of Family Medicine, Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada.

出版信息

BMC Emerg Med. 2021 Mar 17;21(1):32. doi: 10.1186/s12873-021-00428-0.

Abstract

BACKGROUND

On October 17, 2018, the Cannabis Act decriminalized the recreational use of cannabis in Canada. This study seeks to determine how legalization of cannabis has impacted emergency department (ED) visits for acute cannabis intoxication.

METHODS

We conducted a retrospective chart review at an academic ED in Hamilton, Ontario. We assessed all visits with a cannabis-related ICD-10 discharge code 6 months before and after legalization (October 17, 2018) to determine cases of acute cannabis intoxication. The primary outcome was the rate of ED visits. Secondary outcomes included number of visits distributed by age, length of stay, co-ingestions, and clinical course in the emergency department (investigations and treatment).

RESULTS

There was no difference in the overall rate of ED visits following legalization (2.44 vs. 2.94 visits/1000, p = 0.27). However, we noted a 56% increase in visits among adults aged 18-29 (p = 0.03). Following legalization, a larger portion of patients required observation without interventions (25% vs 48%, p < 0.05). Bloodwork and imaging studies decreased (53% vs. 12%, p < 0.05; 29% vs. 2%, p < 0.05); however, treatment with benzodiazepines increased (24% vs. 51%, p < 0.05).

CONCLUSIONS

Legalization was not associated with a change in the rate of cannabis-related ED visits in our study. More research is needed regarding changing methods of cannabis ingestion and trends among specific age groups.

摘要

背景

2018 年 10 月 17 日,《大麻法案》使娱乐用大麻在加拿大合法化。本研究旨在确定大麻合法化如何影响因急性大麻中毒而到急诊就诊的情况。

方法

我们在安大略省汉密尔顿的一家学术急诊进行了回顾性图表审查。我们评估了合法化前 6 个月(2018 年 10 月 17 日)和之后所有与大麻相关的 ICD-10 出院代码的就诊情况,以确定急性大麻中毒的病例。主要结果是急诊就诊率。次要结果包括按年龄分布的就诊次数、停留时间、合并摄入和急诊科室的临床过程(检查和治疗)。

结果

合法化后急诊就诊的总体率没有差异(2.44 与 2.94 就诊/1000,p=0.27)。然而,我们注意到 18-29 岁成年人的就诊人数增加了 56%(p=0.03)。合法化后,更多的患者需要观察而无需干预(25%与 48%,p<0.05)。血液检查和影像学研究减少(53%与 12%,p<0.05;29%与 2%,p<0.05);然而,苯二氮䓬类药物的治疗增加(24%与 51%,p<0.05)。

结论

在我们的研究中,合法化与因大麻相关的急诊就诊率变化无关。需要更多关于改变大麻摄入方式和特定年龄组趋势的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5ad/7968301/3c5b3e4c707d/12873_2021_428_Fig1_HTML.jpg

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