School of Public Health, University of Alberta, Edmonton, AB, Canada.
Dept. Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
NPJ Biofilms Microbiomes. 2021 Mar 17;7(1):25. doi: 10.1038/s41522-021-00201-y.
Human respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission.
人类呼吸道合胞病毒（RSV）是全球儿童和免疫功能低下成年人急性呼吸道感染的主要原因。在这里，我们报告说，变形虫释放含有高浓度传染性 RSV 的可呼吸大小的囊泡，这些囊泡在整个实验过程中持续存在。鉴于变形虫在潮湿环境中的普遍性，我们的结果表明，细胞外变形虫囊泡可能有助于呼吸道病毒在环境中的持续存在，包括对消毒过程的潜在抗性，从而为病毒的传播和传播提供新的途径。
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