Lin Yuwan, Zhou Miaomiao, Dai Wei, Guo Wenyuan, Qiu Jiewen, Zhang Zhiling, Mo Mingshu, Ding Liuyan, Ye Panghai, Wu Yijuan, Zhu Xiaoqin, Wu Zhuohua, Xu Pingyi, Chen Xiang
Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Front Aging Neurosci. 2021 Feb 24;13:634213. doi: 10.3389/fnagi.2021.634213. eCollection 2021.
: Parkinson's disease (PD) and osteoporosis are both common aging diseases. It is reported that PD has a close relationship with osteoporosis and bone secretory proteins may be involved in disease progression. : To detect the bone-derived factors in plasma and cerebrospinal fluid (CSF) of patients with PD and evaluate their correlations with C-reaction protein (CRP) level, motor impairment, and Hoehn-Yahr (HY) stage of the disease. : We included 250 PD patients and 250 controls. Levels of osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), Sclerostin (SO), Bone morphogenetic protein 2 (BMP2), and Dickkopf-1 (DKK-1) in plasma and CSF were measured by custom protein antibody arrays. Data were analyzed using Mann-Whitney -test and Spearman's receptor activator of NF-κB (RANK) correlation. : Plasma levels of OCN and OPN were correlated with CRP levels and HY stage and motor impairment of PD. Furthermore, the plasma assessment with CSF detection may enhance their potential prediction on PD. : OCN and OPN may serve as potential biomarkers for PD. The inflammation response may be involved in the cross-talk between the two factors and PD.
帕金森病（PD）和骨质疏松症都是常见的衰老相关疾病。据报道，PD与骨质疏松症关系密切，骨分泌蛋白可能参与疾病进展。：检测PD患者血浆和脑脊液（CSF）中的骨源性因子，并评估它们与C反应蛋白（CRP）水平、运动障碍以及疾病的 Hoehn-Yahr（HY）分期的相关性。：我们纳入了250例PD患者和250例对照。通过定制蛋白抗体阵列检测血浆和CSF中骨钙素（OCN）、骨桥蛋白（OPN）、骨保护素（OPG）、硬化蛋白（SO）、骨形态发生蛋白2（BMP2）和Dickkopf-1（DKK-1）的水平。使用Mann-Whitney检验和Spearman的NF-κB受体激活剂（RANK）相关性分析数据。：血浆中OCN和OPN的水平与CRP水平、HY分期以及PD的运动障碍相关。此外，血浆评估结合CSF检测可能增强它们对PD的潜在预测能力。：OCN和OPN可能作为PD的潜在生物标志物。炎症反应可能参与这两种因子与PD之间的相互作用。
