对年龄相关性黄斑变性中视网膜色素上皮细胞表观遗传功能障碍的进一步理解。
Further understanding of epigenetic dysfunction of the retinal pigment epithelium in AMD.
作者信息
Kenney Maria Cristina, Nashine Sonali
机构信息
Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA, USA.
Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
出版信息
Expert Rev Ophthalmol. 2020;15(4):221-231. doi: 10.1080/17469899.2020.1767597. Epub 2020 Jun 25.
INTRODUCTION
Modulation of epigenetic mechanisms that contribute to retinal development may render the eye susceptible to age-related macular degeneration (AMD). Progression of AMD involves alterations of epigenome such as CpG methylation and histone modifications, and study of the epigenetic regulation of molecular/ cellular pathways associated with AMD might identify target epigenetic markers for treatment of AMD.
AREAS COVERED
In this review, we provide an overview of the influence of epigenetic factors on signaling pathways/ related genes associated with AMD, mainly hypoxia, angiogenesis, inflammation, complement, and oxidative stress; and discuss the critical role of microRNAs in AMD.
EXPERT OPINION
Better understanding of epigenetic-mediated and microRNA-mediated regulation of the AMD disease-related pathways would help to assess the risk of developing AMD besides providing valuable insight on potential target candidates for AMD therapy.
引言
对视网膜发育起作用的表观遗传机制的调节可能使眼睛易患年龄相关性黄斑变性（AMD）。AMD的进展涉及表观基因组的改变，如CpG甲基化和组蛋白修饰，对与AMD相关的分子/细胞途径的表观遗传调控的研究可能会确定治疗AMD的表观遗传靶点。
涵盖领域
在本综述中，我们概述了表观遗传因素对与AMD相关的信号通路/相关基因的影响，主要包括缺氧、血管生成、炎症、补体和氧化应激；并讨论了微小RNA在AMD中的关键作用。
专家观点
更好地理解表观遗传介导和微小RNA介导的对AMD疾病相关途径的调节，除了能为AMD治疗的潜在靶点提供有价值的见解外，还将有助于评估患AMD的风险。
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