Yang Xiaoxiao, Xu Xuewen, Zhu Haitao, Wang Ming, Wang Dongqing
Department of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212031, P.R. China.
Oncol Lett. 2021 Apr;21(4):308. doi: 10.3892/ol.2021.12569. Epub 2021 Feb 21.
Digestive system tumors are the most common cause of cancer-associated mortality worldwide, although their underlying biological behavior still requires further investigation. Most of the studies that have been published have been based on the two-dimensional (2D) culture system. However, digestive system tumors exhibit considerable histological and functional heterogeneity, and clonal diversity and heterogeneity cannot be entirely reflected in the 2D culture system. Recently, the development of organoids appears to have shed some light on this area of cancer research. The present review discusses the recent advancements that have been made in the development of several specific organoids in digestive system solid tumors.
消化系统肿瘤是全球癌症相关死亡的最常见原因，尽管其潜在的生物学行为仍需进一步研究。已发表的大多数研究都是基于二维（2D）培养系统。然而，消化系统肿瘤表现出相当大的组织学和功能异质性，并且克隆多样性和异质性在二维培养系统中不能完全体现。最近，类器官的发展似乎为癌症研究的这一领域带来了一些启示。本综述讨论了消化系统实体瘤中几种特定类器官发展的最新进展。
