Li Jiao, Zhou Mengting, Xie Jun, Chen Jiani, Yang Mengni, Ye Changjun, Cheng Shihu, Liu Miao, Li Rui, Tan Ruirong
Translational Chinese Medicine Key Laboratory of Sichuan, Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
West China School of Pharmacy, Sichuan University, Chengdu, China.
Cell Death Discov. 2024 Sep 27;10(1):410. doi: 10.1038/s41420-024-02186-x.
Diseases of the female reproductive system, especially malignant tumors, pose a serious threat to women's health worldwide. One of the key factors limiting research progress in this area is the lack of representative models. Organoid technology, especially tumor organoids, has been increasingly applied in the study of female reproductive system tumors due to their high heterogeneity, close resemblance to the physiological state, easy acquisition and cultivation advantages. They play a significant role in understanding the origin and causes of tumors, drug screening, and personalized treatment and more. This article reviews the organoid models for the female reproductive system, focusing on the cancer research advancements. It discusses the methods for constructing tumor organoids of the female reproductive tract and summarizes the limitations of current research. The aim is to offer a reference for future development and application of these organoid models, contributing to the advancement of anti-tumor drugs and treatment strategies for female reproductive tract cancer patients.
女性生殖系统疾病，尤其是恶性肿瘤，在全球范围内对女性健康构成严重威胁。限制该领域研究进展的关键因素之一是缺乏代表性模型。类器官技术，尤其是肿瘤类器官，因其高度异质性、与生理状态高度相似、易于获取和培养等优点，已越来越多地应用于女性生殖系统肿瘤的研究。它们在理解肿瘤的起源和病因、药物筛选以及个性化治疗等方面发挥着重要作用。本文综述了女性生殖系统的类器官模型，重点介绍癌症研究进展。讨论了构建女性生殖道肿瘤类器官的方法，并总结了当前研究的局限性。目的是为这些类器官模型的未来发展和应用提供参考，推动女性生殖道癌症患者抗肿瘤药物和治疗策略的进步。
