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Rituximab therapy for a severe case of pretibial myxedema.

作者信息

Jimenez Amber, Hull Christopher, Zone John

机构信息

University of Utah School of Medicine, Salt Lake City, Utah.

Department of Dermatology, University of Utah, Salt Lake City, Utah.

出版信息

JAAD Case Rep. 2021 Feb 3;10:28-30. doi: 10.1016/j.jdcr.2021.01.033. eCollection 2021 Apr.

DOI:10.1016/j.jdcr.2021.01.033
PMID:33732842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7940995/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5858/7940995/e033da285de1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5858/7940995/e033da285de1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5858/7940995/e033da285de1/gr1.jpg

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Rituximab therapy for a severe case of pretibial myxedema.利妥昔单抗治疗严重胫前黏液性水肿一例
JAAD Case Rep. 2021 Feb 3;10:28-30. doi: 10.1016/j.jdcr.2021.01.033. eCollection 2021 Apr.
2
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial Myxedema: A Case Series.利妥昔单抗联合静脉注射免疫球蛋白治疗胫前黏液水肿的临床经验：病例系列研究。
Thyroid. 2019 May;29(5):692-699. doi: 10.1089/thy.2018.0706. Epub 2019 Apr 8.
3
Local immune microenvironment of skin may play an important role in the development of pretibial myxedema.皮肤局部免疫微环境可能在胫前黏液水肿的发病中起重要作用。
Exp Dermatol. 2021 Dec;30(12):1820-1824. doi: 10.1111/exd.14402. Epub 2021 Jun 11.
4
TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema.格雷夫斯眼病和胫前黏液性水肿患者眼眶及胫前成纤维细胞中的促甲状腺激素受体转录本及促甲状腺激素受体样免疫反应性
Thyroid. 1997 Feb;7(1):3-12. doi: 10.1089/thy.1997.7.3.
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[Pretibial myxedema: pathogenetic features and clinical aspects].[胫前黏液性水肿：发病机制特点与临床方面]
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Pretibial Myxedema Presenting as Severe Elephantiasis.表现为严重象皮肿的胫前黏液性水肿
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TSH and TSH receptor antibody-binding sites in fibroblasts of pretibial myxedema are related to the extracellular domain of entire TSH receptor.胫前黏液性水肿成纤维细胞中的促甲状腺激素（TSH）和TSH受体抗体结合位点与完整TSH受体的细胞外结构域相关。
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Euthyroid pretibial myxedema.甲状腺功能正常的胫前黏液性水肿
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Pretibial myxedema: pathophysiology and treatment options.胫前黏液性水肿：病理生理学与治疗选择
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Pretibial Myxedema in a Euthyroid Patient.一名甲状腺功能正常患者的胫前黏液性水肿。
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引用本文的文献

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Pretibial myxedema treated with intralesional tumescent drug delivery of hyaluronidase, triamcinolone, vitamin B12, and sodium bicarbonate dissolved in a tumescent epinephrine lidocaine solution.采用肿胀液肾上腺素利多卡因溶液溶解透明质酸酶、曲安奈德、维生素B12和碳酸氢钠进行皮损内肿胀液药物注射治疗胫前黏液性水肿。
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Graves' disease complicated by concurrent thyroid eye disease and pretibial myxedema successfully treated with teprotumumab.用替普罗单抗成功治疗并发甲状腺眼病和胫前黏液性水肿的格雷夫斯病。
Clin Case Rep. 2022 Nov 19;10(11):e6621. doi: 10.1002/ccr3.6621. eCollection 2022 Nov.
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本文引用的文献

1
Graves' disease: Clinical manifestations, immune pathogenesis (cytokines and chemokines) and therapy.格雷夫斯病：临床表现、免疫发病机制（细胞因子和趋化因子）和治疗。
Best Pract Res Clin Endocrinol Metab. 2020 Jan;34(1):101388. doi: 10.1016/j.beem.2020.101388. Epub 2020 Feb 4.
2
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial Myxedema: A Case Series.利妥昔单抗联合静脉注射免疫球蛋白治疗胫前黏液水肿的临床经验：病例系列研究。
Thyroid. 2019 May;29(5):692-699. doi: 10.1089/thy.2018.0706. Epub 2019 Apr 8.
3
Rituximab in the Treatment of Thyroid Eye Disease: A Review.
Insidious-Onset Indurated Plaques on the Shins.
隐匿性起病的小腿硬结性斑块。
Dermatopathology (Basel). 2021 Jun 6;8(2):185-189. doi: 10.3390/dermatopathology8020024.
利妥昔单抗治疗甲状腺眼病：综述
Neuroophthalmology. 2015 Jun 17;39(3):109-115. doi: 10.3109/01658107.2015.1039140. eCollection 2015 Jun.
4
Treatment-resistant elephantiasic thyroid dermopathy responding to rituximab and plasmapheresis.对利妥昔单抗和血浆置换有反应的难治性象皮病性甲状腺皮肤病。
Australas J Dermatol. 2012 Feb;53(1):e1-4. doi: 10.1111/j.1440-0960.2010.00693.x. Epub 2010 Sep 10.
5
Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project.利妥昔单抗治疗HIV阴性患者后发生的进行性多灶性白质脑病：来自药物不良事件及报告项目研究的57例报告
Blood. 2009 May 14;113(20):4834-40. doi: 10.1182/blood-2008-10-186999. Epub 2009 Mar 5.
6
Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations.自身免疫性甲状腺疾病：病因、发病机制及皮肤表现。
J Am Acad Dermatol. 2003 May;48(5):641-59; quiz 660-2. doi: 10.1067/mjd.2003.257.
7
Dermopathy of Graves disease (pretibial myxedema). Review of 150 cases.格雷夫斯病的皮肤病变（胫前黏液性水肿）。150例病例回顾。
Medicine (Baltimore). 1994 Jan;73(1):1-7. doi: 10.1097/00005792-199401000-00001.