Department of Business and Economics, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.
Department of Cardiology, Zealand University Hospital Roskilde, Sygehusvej 10, 4000, Roskilde, Denmark.
Eur J Health Econ. 2021 Jun;22(4):621-628. doi: 10.1007/s10198-021-01279-z. Epub 2021 Mar 18.
EQ-5D is a generic instrument to measure health-related quality of life. In 2009, a new version, EQ-5D-5L, was introduced as an attempt to reduce ceiling effects and improve sensitivity to small changes over time. The objective of this study was to assess the measurement properties of the EQ-5D-5L instrument compared to the EQ-5D-3L instrument in an elderly general population with a moderate to a high degree of comorbidity. A subgroup of participants in a large clinical trial completed the EQ-5D-3L and the EQ-5D-5L questionnaires. Based on the collected data, we tested for feasibility and ceiling and floor effects. Furthermore, we assessed the redistribution properties of the responses and examined the level of inconsistency, informativity, and convergent validity. A total of 1002 persons diagnosed with hypertension, diabetes, heart failure, and/or previous stroke completed both the EQ-5D-3L and the EQ-5D-5L questionnaires. The overall ceiling effect decreased from 46% with the EQ-5D-3L to 30% with the EQ-5D-5L and absolute and relative informativity were higher for EQ-5D-5L, and there was a stronger correlation between EQ-5D-5L and EQ VAS. The EQ-5D-5L seemed to perform better than the EQ-5D-3L in terms of feasibility, ceiling effect, discriminatory power, and convergent validity. The overall ceiling effect was higher than that found in patient samples in previous studies but lower than the one found in population studies.
EQ-5D 是一种通用的测量健康相关生活质量的工具。2009 年，推出了一个新版本 EQ-5D-5L，旨在减少天花板效应并提高对随时间变化的小变化的敏感性。本研究的目的是评估 EQ-5D-5L 仪器与 EQ-5D-3L 仪器在患有中度至高度共病的老年普通人群中的测量特性。大型临床试验的一部分参与者完成了 EQ-5D-3L 和 EQ-5D-5L 问卷。基于收集的数据，我们测试了可行性和天花板及地板效应。此外，我们评估了响应的重新分配特性，并检查了不一致性、信息量和收敛有效性的水平。共有 1002 名被诊断患有高血压、糖尿病、心力衰竭和/或先前中风的人完成了 EQ-5D-3L 和 EQ-5D-5L 问卷。整体天花板效应从 EQ-5D-3L 的 46%下降到 EQ-5D-5L 的 30%，EQ-5D-5L 的绝对和相对信息量更高，EQ-5D-5L 与 EQ VAS 之间的相关性更强。EQ-5D-5L 在可行性、天花板效应、区分能力和收敛有效性方面似乎优于 EQ-5D-3L。整体天花板效应高于以前研究中在患者样本中发现的效应，但低于在人群研究中发现的效应。
