Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Science University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Biomedical Sciences Department, University Center of Tonalá, University of Guadalajara, Tonalá, Jalisco, México.
J Med Food. 2021 Oct;24(10):1017-1027. doi: 10.1089/jmf.2020.0206. Epub 2021 Mar 17.
The global rise in the prevalence of metabolic diseases such as diabetes, obesity, and dyslipidemia is a serious public health issue. The search for safe and effective complementary and alternative therapies to treat metabolic disorders is a key field of research. (MC) is a tropical and subtropical vine of the Cucurbitaceae family used as a medicinal plant since ancient times. Although MC has been widely studied for its hypoglycemic potential, hypolipidemic and antiobesity effects have also been reported in preclinical studies and clinical trials. This study aims to review the metabolic effects of MC reported in clinical trials as well as its mechanisms of action.
全球范围内代谢性疾病（如糖尿病、肥胖症和血脂异常）的患病率不断上升，这是一个严重的公共卫生问题。寻找安全有效的补充和替代疗法来治疗代谢紊乱是一个关键的研究领域。苦瓜（Momordica charantia）是一种热带和亚热带的葫芦科藤蔓植物，自古以来就被用作药用植物。尽管苦瓜的降血糖潜力已得到广泛研究，但临床前研究和临床试验也报道了其具有降血脂和抗肥胖作用。本研究旨在综述临床试验中苦瓜的代谢作用及其作用机制。
