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血小板透明质酸酶 2 在急性冠状动脉综合征中的富集：在单核细胞-血小板聚集形成中的推测作用。

Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation.

机构信息

Catholic University of the Sacred Heart, Rome, Italy.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

出版信息

J Enzyme Inhib Med Chem. 2021 Dec;36(1):785-789. doi: 10.1080/14756366.2021.1900159.

DOI:10.1080/14756366.2021.1900159
PMID:33733989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7993372/
Abstract

Acute Coronary Syndromes (ACS) with plaque erosion display dysregulated hyaluronan metabolism, with increased hyaluronidase-2 (HYAL2) expression. However, the expression and the role of this enzyme on platelets has never been explored. We evaluated the platelet's HYAL2 (HYAL2) levels on I) stable angina (SA) and II) ACS patients, furtherly sub-grouped in Intact-Fibrous-Cap (IFC) and Ruptured-Fibrous-Cap (RFC), according to Optical Coherence Tomography. We assessed the HYAL2 role through an model setting of co-cultured monocytes and platelets, before and after treatment with low-molecular-weight hyaluronic acid (HA) as pro-inflammatory stimulus and with or without HYAL2-antibody to inhibit HYAL2 activity. ACS patients exhibit higher HYAL2 levels comparing to SA, with the higher expression for IFC group. The addition of HYAL2-antibody significantly reduced the percentage of monocyte-platelet binding, suggesting that HYAL2 enrichment at the site of the culprit lesion is a key mediator in the systemic thrombo-inflammatory status of ACS presenting with plaque erosion.

摘要

急性冠状动脉综合征 (ACS) 伴斑块糜烂显示透明质酸代谢失调，透明质酸酶-2 (HYAL2) 表达增加。然而，这种酶在血小板上的表达和作用从未被探索过。我们评估了 I) 稳定性心绞痛 (SA) 和 II) ACS 患者的血小板 HYAL2 (HYAL2) 水平，根据光学相干断层扫描进一步分为完整纤维帽 (IFC) 和破裂纤维帽 (RFC)。我们通过共培养单核细胞和血小板的模型设置来评估 HYAL2 的作用，该模型设置在接受低分子量透明质酸 (HA) 作为促炎刺激物治疗前后进行，并且是否存在抑制 HYAL2 活性的 HYAL2 抗体。ACS 患者的 HYAL2 水平明显高于 SA，IFC 组的表达更高。添加 HYAL2 抗体可显著降低单核细胞-血小板结合的百分比，表明在易损斑块糜烂的 ACS 中，HYAL2 在罪犯病变部位的富集是全身血栓炎症状态的关键介质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/df0ccfc457ee/IENZ_A_1900159_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/48576a7ae773/IENZ_A_1900159_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/17ff3133e685/IENZ_A_1900159_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/df0ccfc457ee/IENZ_A_1900159_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/48576a7ae773/IENZ_A_1900159_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/17ff3133e685/IENZ_A_1900159_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/597b/7993372/df0ccfc457ee/IENZ_A_1900159_F0002_C.jpg

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