Anzurez Alitzel, Naka Izumi, Miki Shoji, Nakayama-Hosoya Kaori, Isshiki Mariko, Watanabe Yusuke, Nakamura-Hoshi Midori, Seki Sayuri, Matsumura Takayuki, Takano Tomohiro, Onodera Taishi, Adachi Yu, Moriyama Saya, Terahara Kazutaka, Tachikawa Natsuo, Yoshimura Yoshihiro, Sasaki Hiroaki, Horiuchi Hiroshi, Miyata Nobuyuki, Miyazaki Kazuhito, Koga Michiko, Ikeuchi Kazuhiko, Nagai Hiroyuki, Saito Makoto, Adachi Eisuke, Yotsuyanagi Hiroshi, Kutsuna Satoshi, Kawashima Akira, Miyazato Yusuke, Kinoshita Noriko, Kouno Chiyoko, Tanaka Kensuke, Takahashi Yoshimasa, Suzuki Tadaki, Matano Tetsuro, Ohashi Jun, Kawana-Tachikawa Ai
AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
HLA. 2021 Jul;98(1):37-42. doi: 10.1111/tan.14256. Epub 2021 Apr 13.
HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB109:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB109:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.
对178名日本新冠肺炎患者的HLA-A、-C、-B和-DRB1基因型进行分析，以研究HLA与重症新冠肺炎的关联。对四个位点的32个常见HLA等位基因进行分析发现，在调整年龄、性别和DRB1位点的其他常见HLA等位基因后，HLA-DRB109:01与重症新冠肺炎之间存在显著关联（优势比[OR]为3.62；95%置信区间为1.57-8.35；p = 0.00251[置换p值=0.0418]）。与高血压、糖尿病和心血管疾病等既往疾病相比，DRB109:01等位基因与重症新冠肺炎风险的关联更为显著。这些结果表明HLA在重症新冠肺炎易感性中可能发挥作用。
