Elevated Expression Is Associated with Gastric Tumorigenesis and Infiltration of M2-Polarized Macrophages in the Gastric Tumor Immune Microenvironment.

To assess the expression and epigenetic regulation of Syncoilin, intermediate filament protein () in gastric cancer tissues, and to determine its associations with clinicopathological features; immune infiltration of macrophages in tumors; and patient survival. Clinicopathological features, expression profiles, and methylation data of the gene were obtained from multi-institutional real-world public datasets. A total of 1601 samples from patients with gastric cancer were examined. The associations between clinicopathological features and expression levels were assessed by the chi-square test; survival was assessed using the Kaplan-Meier analysis. The infiltration levels of M1, 2-polarized tumor-associated macrophages (TAMs) in a gastric tumor immune microenvironment were quantified using deconvolution, and the correlation between expression level and M1, 2-polarized macrophages' infiltration was examined using the Pearson correlation test. gene methylation data were analyzed to investigate epigenetic control of its expression. expression was elevated in gastric cancer tissues ( < 0.01), and was associated with a poorer overall survival ( < 0.01) and poorer postprogression survival ( = 0.01). Higher levels were significantly associated with more aggressive clinicopathological features in gastric cancer patients ( < 0.05). was also associated with the infiltration of M2-polarized TAMs in the gastric tumor immune microenvironment ( < 0.001). Hypomethylation was shown to be associated with s upregulation ( < 0.05). is highly expressed in gastric cancer tissues and has the potential to be a therapeutic target and to serve as a prognostic marker.