1 小时口服葡萄糖耐量试验对成年囊性纤维化患者 4 年临床状况的影响。
Impact of 1h oral glucose tolerance test on the clinical status of adult cystic fibrosis patients over a 4-year period.
机构信息
Montreal Clinical Research Institute, Québec, Canada.
Département de nutrition et de Médecine, Université de Montréal, Montréal, Québec, Canada.
出版信息
PLoS One. 2021 Mar 18;16(3):e0246897. doi: 10.1371/journal.pone.0246897. eCollection 2021.
OBJECTIVE
To report the clinical profile associated with G60 and I60 over a 4-year prospective observational period in 2 large cohorts of adult patients with CF.
METHODS
319 patients were included (210 Canadian and 119 French) and classified according to their inclusion G60 (≥ or < 11.1 mmol/L) and the median inclusion I60 (≥ or < 24 mU/I). Forced expiratory volume in 1 second (FEV1), body mass index (BMI) were collected on OGTT days. Linear mixed regression models were used to assess the effect of G60 and I60.
RESULTS
High G60 was not associated to a lower FEV1 at inclusion and the follow-up decline was not higher in the high G60 group (Coefficient [95% CI]: -3.4 [-7.4;0.6], p = 0.0995.). There was no significant association between BMI and G60. Patients with high I60 tended to have a higher mean BMI (+0.5 kg/m2 [0.0 to 1.1], p = 0.05) but no interaction over time was observed.
CONCLUSIONS
High G60 is not associated with a lower lung function at inclusion nor its decline over a 4-year follow-up. High I60 is slightly associated to a higher weight at inclusion, but not with BMI evolution over time in adult patients.
目的
报告在 2 个大型成年 CF 患者队列中，经过 4 年的前瞻性观察，与 G60 和 I60 相关的临床特征。
方法
纳入 319 名患者（210 名加拿大患者和 119 名法国患者），根据纳入时的 G60（≥或<11.1mmol/L）和 I60 中位数（≥或<24mU/I）进行分类。在 OGTT 日收集 1 秒用力呼气量（FEV1）和体重指数（BMI）。采用线性混合回归模型评估 G60 和 I60 的影响。
结果
高 G60 与纳入时较低的 FEV1 无关，高 G60 组的随访下降也不高（系数[95%CI]：-3.4[-7.4;0.6]，p=0.0995）。BMI 与 G60 之间没有显著关联。高 I60 患者的平均 BMI 略高（+0.5kg/m2[0.0 至 1.1]，p=0.05），但未观察到随时间的交互作用。
结论
高 G60 与纳入时较低的肺功能或 4 年随访期间的肺功能下降无关。高 I60 与纳入时的体重较高略有关联，但与成年患者 BMI 的随时间演变无关。
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