• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

结合病毒遗传和动物移动性网络数据揭示西非小反刍兽疫的传播动态。

Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa.

机构信息

ASTRE, Univ Montpellier, CIRAD, INRAE, Montpellier, France.

CIRAD, UMR ASTRE, Montpellier, France.

出版信息

PLoS Pathog. 2021 Mar 18;17(3):e1009397. doi: 10.1371/journal.ppat.1009397. eCollection 2021 Mar.

DOI:10.1371/journal.ppat.1009397
PMID:33735294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8009415/
Abstract

Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential "hotspots" for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility.

摘要

小反刍兽疫（PPR）是一种致命的病毒性疾病，主要影响小型家养反刍动物。这种疾病威胁着全球粮食安全和农村经济，但由于受感染地区广泛、监测不力的动物流动，其控制变得复杂。在这里，我们将该地区有史以来收集到的最大规模的 PPR 病毒遗传和动物流动网络数据结合起来，以增进我们对西非国家 PPR 地方性传播动态的了解。系统发育分析确定了存在多个 PPRV 遗传分支，这些分支可能被视为在西非同时平行进化的不同传播网络的一部分。病毒遗传距离与网络相关距离之间存在很强的相关性。在同一流动社区内采样的病毒更有可能属于同一遗传分支。这些结果为动物流动在该地区 PPR 传播中的重要性提供了证据。网络中的一些节点与属于不同分支的 PPRV 序列相关，代表 PPR 循环的潜在“热点”。我们的结果表明，结合遗传和流动网络数据可以帮助确定在特定地区对病毒进入和传播至关重要的地点。此类信息可以提高我们利用动物流动等风险因素制定适应当地情况的控制和监测策略的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/2c566eb961d9/ppat.1009397.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/afaf132e582d/ppat.1009397.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/8bb1e0538dc5/ppat.1009397.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/5ab056800632/ppat.1009397.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/fd18c575033c/ppat.1009397.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/f24cc6549f4b/ppat.1009397.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/08ca6095426e/ppat.1009397.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/2c566eb961d9/ppat.1009397.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/afaf132e582d/ppat.1009397.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/8bb1e0538dc5/ppat.1009397.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/5ab056800632/ppat.1009397.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/fd18c575033c/ppat.1009397.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/f24cc6549f4b/ppat.1009397.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/08ca6095426e/ppat.1009397.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b477/8009415/2c566eb961d9/ppat.1009397.g007.jpg

相似文献

1
Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa.结合病毒遗传和动物移动性网络数据揭示西非小反刍兽疫的传播动态。
PLoS Pathog. 2021 Mar 18;17(3):e1009397. doi: 10.1371/journal.ppat.1009397. eCollection 2021 Mar.
2
Peste des petits ruminants in Africa: Meta-analysis of the virus isolation in molecular epidemiology studies.非洲小反刍兽疫：分子流行病学研究中病毒分离的荟萃分析
Onderstepoort J Vet Res. 2019 Mar 26;86(1):e1-e15. doi: 10.4102/ojvr.v86i1.1677.
3
Retrospective Characterization of Initial Peste des petits ruminants Outbreaks (2008-2012) in the Democratic Republic of the Congo.刚果民主共和国 2008-2012 年小反刍兽疫首次暴发的回顾性特征描述。
Viruses. 2021 Nov 26;13(12):2373. doi: 10.3390/v13122373.
4
Co-circulation of Peste-des-Petits-Ruminants Virus Asian lineage IV with Lineage II in Nigeria.尼日利亚小反刍兽疫病毒亚洲IV型与II型的共同流行。
Transbound Emerg Dis. 2016 Jun;63(3):235-42. doi: 10.1111/tbed.12387. Epub 2015 Jun 12.
5
Wide circulation of peste des petits ruminants virus in sheep and goats across Nigeria.尼日利亚绵羊和山羊中广泛传播小反刍兽疫病毒。
Onderstepoort J Vet Res. 2021 Sep 7;88(1):e1-e7. doi: 10.4102/ojvr.v88i1.1899.
6
Molecular characterization of Peste des Petits ruminants virus isolated from four outbreaks occurred in southern Iran.从伊朗南部四起疫情中分离出的小反刍兽疫病毒的分子特征。
BMC Vet Res. 2019 May 28;15(1):177. doi: 10.1186/s12917-019-1920-y.
7
Molecular epidemiology of peste des petits ruminants in Niger: An update.尼日尔小反刍兽疫的分子流行病学：最新进展。
Transbound Emerg Dis. 2020 May;67(3):1388-1392. doi: 10.1111/tbed.13451. Epub 2019 Dec 27.
8
Prevalence of peste des petits ruminants virus antibodies in sheep and goats sera from Central-Western Sudan.苏丹中西部绵羊和山羊血清中小反刍兽疫病毒抗体的流行情况。
Onderstepoort J Vet Res. 2023 Feb 28;90(1):e1-e8. doi: 10.4102/ojvr.v90i1.2074.
9
Molecular characterization of peste des petits ruminants viruses from outbreaks caused by unrestricted movements of small ruminants in pakistan.巴基斯坦小反刍兽疫病毒的分子特征分析：源于小反刍动物无限制流动引发的疫情
Transbound Emerg Dis. 2015 Feb;62(1):108-14. doi: 10.1111/tbed.12089. Epub 2013 Apr 17.
10
Seroprevalence and risk factors for peste des petits ruminants in sheep and goats in Djibouti.吉布提绵羊和山羊小反刍兽疫的血清流行率及危险因素
Rev Sci Tech. 2018 Dec;37(3):961-969. doi: 10.20506/37.3.2899.

引用本文的文献

1
GPS-Based Hidden Markov Models to Document Pastoral Mobility in the Sahel.基于 GPS 的隐马尔可夫模型在萨赫勒地区记录游牧迁徙历史。
Sensors (Basel). 2024 Oct 30;24(21):6964. doi: 10.3390/s24216964.
2
Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication.经验和基于模型的证据表明，牛在小反刍兽疫病毒传播和根除中的作用可以忽略不计。
Commun Biol. 2024 Aug 3;7(1):937. doi: 10.1038/s42003-024-06619-2.
3
Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages.

本文引用的文献

1
Mapping livestock movements in Sahelian Africa.绘制萨赫勒非洲的牲畜流动图。
Sci Rep. 2020 May 20;10(1):8339. doi: 10.1038/s41598-020-65132-8.
2
Application of Mixed Methods to Identify Small Ruminant Disease Priorities in Ethiopia.运用混合方法确定埃塞俄比亚小反刍动物疾病的优先事项
Front Vet Sci. 2019 Nov 26;6:417. doi: 10.3389/fvets.2019.00417. eCollection 2019.
3
Pastoralist knowledge of sheep and goat disease and implications for peste des petits ruminants virus control in the Afar Region of Ethiopia.埃塞俄比亚阿法尔地区牧民对绵羊和山羊疾病的了解及其对小反刍兽疫病毒控制的影响。
小反刍兽疫病毒基因谱系的比较进化分析
Virus Evol. 2024 Mar 6;10(1):veae012. doi: 10.1093/ve/veae012. eCollection 2024.
4
Molecular Epidemiology of Peste Des Petits Ruminants Virus in West Africa: Is Lineage IV Replacing Lineage II in Burkina Faso?西非小反刍兽疫病毒的分子流行病学：IV 谱系是否正在取代布基纳法索的 II 谱系？
Viruses. 2024 Feb 3;16(2):244. doi: 10.3390/v16020244.
5
Environmental and economic determinants of temporal dynamics of the ruminant movement network of Senegal.塞内加尔反刍动物移动网络时间动态的环境和经济决定因素。
Sci Rep. 2023 Sep 2;13(1):14482. doi: 10.1038/s41598-023-40715-3.
6
Epidemiologic and import risk analysis of Peste des petits ruminants between 2010 and 2018 in India.2010 年至 2018 年期间印度小反刍兽疫的流行病学和输入风险分析。
BMC Vet Res. 2022 Nov 29;18(1):419. doi: 10.1186/s12917-022-03507-x.
7
Complex network analysis to understand trading partnership in French swine production.采用复杂网络分析方法理解法国生猪生产中的交易伙伴关系。
PLoS One. 2022 Apr 7;17(4):e0266457. doi: 10.1371/journal.pone.0266457. eCollection 2022.
8
Molecular epidemiology of peste des petits ruminants virus emergence in critically endangered Mongolian saiga antelope and other wild ungulates.小反刍兽疫病毒在极度濒危的蒙古赛加羚羊及其他野生有蹄类动物中出现的分子流行病学
Virus Evol. 2021 Jun 25;7(2):veab062. doi: 10.1093/ve/veab062. eCollection 2021.
Prev Vet Med. 2020 Jan;174:104808. doi: 10.1016/j.prevetmed.2019.104808. Epub 2019 Nov 1.
4
Incorporating genomic methods into contact networks to reveal new insights into animal behavior and infectious disease dynamics.将基因组方法纳入接触网络，以揭示动物行为和传染病动态的新见解。
Behaviour. 2018 Jan;155(7-9):759-791. doi: 10.1163/1568539X-00003471. Epub 2019 Mar 18.
5
Genetic Evidence for Transboundary Circulation of Peste Des Petits Ruminants Across West Africa.小反刍兽疫在西非跨境传播的遗传学证据
Front Vet Sci. 2019 Aug 21;6:275. doi: 10.3389/fvets.2019.00275. eCollection 2019.
6
Operational Local Join Count Statistics for Cluster Detection.用于聚类检测的操作局部连接计数统计
J Geogr Syst. 2019 Jun;21(2):189-210. doi: 10.1007/s10109-019-00299-x. Epub 2019 May 2.
7
Production and calibration of the second batch of OIE anti-rabies positive reference serum.第二批世界动物卫生组织抗狂犬病阳性参考血清的生产与校准。
Rev Sci Tech. 2017 Dec;36(3):779-788. doi: 10.20506/rst.36.3.2713.
8
First genetic characterization of Peste des Petits Ruminants from Niger: On the advancing front of the Asian virus lineage.尼日尔首例小反刍兽疫病毒的基因特征：在亚洲病毒谱系的前沿推进。
Transbound Emerg Dis. 2018 Oct;65(5):1145-1151. doi: 10.1111/tbed.12901. Epub 2018 Jul 25.
9
Predictive gravity models of livestock mobility in Mauritania: The effects of supply, demand and cultural factors.预测毛里塔尼亚牲畜流动性的重力模型：供应、需求和文化因素的影响。
PLoS One. 2018 Jul 18;13(7):e0199547. doi: 10.1371/journal.pone.0199547. eCollection 2018.
10
Identification of Peste des Petits Ruminants Virus, Georgia, 2016.2016 年格鲁吉亚小反刍兽疫病毒鉴定。
Emerg Infect Dis. 2018 Aug;24(8):1576-1578. doi: 10.3201/eid2408.170334.