Andersson P O, Malmgren A, Uvelius B
Department of Physiology, University of Lund, Sweden.
J Urol. 1988 Jun;139(6):1359-62. doi: 10.1016/s0022-5347(17)42919-3.
Micturition pattern and cystometric characteristics were determined in control rats, and in rats with streptozotocin-induced diabetes (six weeks duration). The diabetic rats had an increased frequency of micturition, an increased micturition volume, and an increased 24 hr. urinary output. The cystometry showed that the diabetic bladders had an increased compliance and a higher threshold volume for initiating a micturition reflex. No spontaneous rhythmic contractions were seen during the filling phase, and no residual urine could be detected. While micturition pressure increased, the micturition time was virtually unaltered. In vitro a right-ward shift for passive and active length-tension relations was noted. The observed changes in cystometric characteristics and length-tension relations might probably be explained on the basis of adaptive changes to the increased diuresis involving both sensory and motor control of the urinary bladder.
在对照大鼠以及链脲佐菌素诱导的糖尿病大鼠（病程六周）中测定排尿模式和膀胱测压特征。糖尿病大鼠排尿频率增加、排尿量增加以及24小时尿量增加。膀胱测压显示，糖尿病膀胱顺应性增加，引发排尿反射的阈值体积更高。充盈期未见自发节律性收缩，也未检测到残余尿。虽然排尿压力增加，但排尿时间基本未改变。在体外，被动和主动长度-张力关系向右移位。膀胱测压特征和长度-张力关系的观察到的变化可能基于对涉及膀胱感觉和运动控制的利尿增加的适应性变化来解释。
