Curley R M, Wagner C H, Murty V N, Belis J A
Division of Urology/Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Pharmacology. 1994 Jul;49(1):61-8. doi: 10.1159/000139217.
Computerized data acquisition was used to achieve a comprehensive assessment of micturition and cystometry in rats made diabetic with streptozotocin. Diabetic rats had a greater mean voided volume and a significantly shorter interval between voiding during the light cycle. During volume expulsion, the rate of intraluminal pressure development was greater, but the mean duration of volume expulsion was less in the diabetic bladder. The increased rate of intraluminal pressure development in the diabetic bladder at the time of volume expulsion correlated with the greater tension development in bladder body strips in response to acetylcholine stimulation. The inability of the diabetic bladder body to maintain peak intraluminal pressure may contribute to the development of residual urine, increased bladder volume and increased voiding frequency in the diabetic rat.
采用计算机化数据采集对链脲佐菌素诱导的糖尿病大鼠的排尿和膀胱测压进行全面评估。糖尿病大鼠在光照周期中的平均排尿量更大，排尿间隔明显更短。在排尿过程中，糖尿病膀胱腔内压力升高的速率更快，但平均排尿持续时间更短。糖尿病膀胱在排尿时腔内压力升高速率的增加与膀胱体条带对乙酰胆碱刺激反应中更大的张力发展相关。糖尿病膀胱体无法维持腔内峰值压力可能导致糖尿病大鼠残余尿量增加、膀胱容量增大和排尿频率增加。
