通过抑制背侧海马体探索记忆相关网络。

Exploring memory-related network via dorsal hippocampus suppression.

作者信息

Han Xu, Cramer Samuel R, Chan Dennis C Y, Zhang Nanyin

机构信息

Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.

The Neuroscience Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.

出版信息

Netw Neurosci. 2024 Dec 10;8(4):1310-1330. doi: 10.1162/netn_a_00401. eCollection 2024.

DOI:10.1162/netn_a_00401

PMID:39735497

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674488/

Abstract

Memory is a complex brain process that requires coordinated activities in a large-scale brain network. However, the relationship between coordinated brain network activities and memory-related behavior is not well understood. In this study, we investigated this issue by suppressing the activity in the dorsal hippocampus (dHP) using chemogenetics and measuring the corresponding changes in brain-wide resting-state functional connectivity (RSFC) and memory behavior in awake rats. We identified an extended brain network contributing to the performance in a spatial memory related task. Our results were cross-validated using two different chemogenetic actuators, clozapine (CLZ) and clozapine-N-oxide (CNO). This study provides a brain network interpretation of memory performance, indicating that memory is associated with coordinated brain-wide neural activities.

摘要

记忆是一个复杂的大脑过程，需要大规模脑网络中的协调活动。然而，脑网络协调活动与记忆相关行为之间的关系尚未得到充分理解。在本研究中，我们通过化学遗传学抑制背侧海马体（dHP）的活动，并测量清醒大鼠全脑静息态功能连接性（RSFC）和记忆行为的相应变化，来研究这个问题。我们确定了一个扩展的脑网络，它对空间记忆相关任务的表现有贡献。我们的结果使用两种不同的化学遗传学促动器氯氮平（CLZ）和氯氮平氮氧化物（CNO）进行了交叉验证。这项研究提供了对记忆表现的脑网络解释，表明记忆与全脑范围内协调的神经活动相关。