Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
BMJ Open. 2021 Mar 17;11(3):e044474. doi: 10.1136/bmjopen-2020-044474.
The Lifelines COVID-19 cohort was set up to assess the psychological and societal impacts of the COVID-19 pandemic and investigate potential risk factors for COVID-19 within the Lifelines prospective population cohort.
Participants were recruited from the 140 000 eligible participants of Lifelines and the Lifelines NEXT birth cohort, who are all residents of the three northern provinces of the Netherlands. Participants filled out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March 2020, and the cohort consists of everyone who filled in at least one questionnaire in the first 8 weeks of the project. FINDINGS TO DATE: >71 000 unique participants responded to the questionnaires at least once during the first 8 weeks, with >22 000 participants responding to seven questionnaires. Compiled questionnaire results are continuously updated and shared with the public through the Corona Barometer website. Early results included a clear signal that younger people living alone were experiencing greater levels of loneliness due to lockdown, and subsequent results showed the easing of anxiety as lockdown was eased in June 2020.
Questionnaires were sent on a (bi)weekly basis starting in March 2020 and on a monthly basis starting July 2020, with plans for new questionnaire rounds to continue through 2020 and early 2021. Questionnaire frequency can be increased again for subsequent waves of infections. Cohort data will be used to address how the COVID-19 pandemic developed in the northern provinces of the Netherlands, which environmental and genetic risk factors predict disease susceptibility and severity and the psychological and societal impacts of the crisis. Cohort data are linked to the extensive health, lifestyle and sociodemographic data held for these participants by Lifelines, a 30-year project that started in 2006, and to data about participants held in national databases.
Lifelines COVID-19 队列的设立是为了评估 COVID-19 大流行对心理和社会的影响，并研究 Lifelines 前瞻性人群队列中 COVID-19 的潜在危险因素。
参与者从 Lifelines 及其 Lifelines NEXT 出生队列的 140000 名合格参与者中招募，他们都是荷兰北部三省的居民。自 2020 年 3 月下旬开始，参与者每周详细填写有关身心健康和经历的问卷，该队列由在前 8 周内至少填写一份问卷的所有人组成。
在头 8 周内，超过 71000 名独特的参与者至少回复了一次问卷，超过 22000 名参与者回复了 7 份问卷。不断更新的汇编问卷结果通过 Corona Barometer 网站与公众共享。早期结果表明，由于封锁，独自生活的年轻人感到更加孤独，随后的结果表明，随着 2020 年 6 月封锁的放松，焦虑感有所缓解。
从 2020 年 3 月开始，每两周发送一次问卷，从 2020 年 7 月开始每月发送一次问卷，并计划在 2020 年和 2021 年初继续进行新的问卷轮次。如果随后出现感染浪潮，可以再次增加问卷频率。队列数据将用于解决 COVID-19 大流行在荷兰北部省份的发展情况，以及哪些环境和遗传风险因素预测疾病易感性和严重程度以及危机的心理和社会影响。队列数据与 Lifelines 持有的这些参与者的广泛健康、生活方式和社会人口数据相关联，Lifelines 是一个始于 2006 年的 30 年项目，并且与参与者在国家数据库中的数据相关联。
