From the Center for Prevention, Lifestyle and Health, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Department of Statistics, Data Science and Modelling, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Epidemiology. 2024 Mar 1;35(2):119-129. doi: 10.1097/EDE.0000000000001693. Epub 2023 Jan 30.
There is debate as to whether a coronavirus infection (SARS-CoV-2) affects older adults' physical activity, sleeping problems, weight, feelings of social isolation, and quality of life (QoL). We investigated differences in these outcomes between older adults with and without coronavirus infection over 180 days following infection.
We included 6789 older adults (65+) from the Lifelines COVID-19 cohort study who provided data between April 2020 and June 2021. Older adults (65+) with and without coronavirus infection were matched on sex, age, education, living situation, body mass index, smoking status, vulnerable health, time of infection, and precoronavirus health outcome. Weighted linear mixed models, adjusted for strictness of governmental policy measures, were used to compare health outcomes after infection between groups.
In total, 309 participants were tested positive for coronavirus. Eight days after infection, older adults with a coronavirus infection engaged in less physical activity, had more sleeping problems, weighed less, felt more socially isolated, and had a lower QoL than those without an infection. Differences in weight, feelings of social isolation, and QoL were absent after 90 days. However, differences in physical activity were still present at 90 days following infection and sleeping problems were present at 180 days.
Our findings found negative associations of coronavirus infection with all the examined outcomes, which for physical activity persisted for 90 days and sleeping problems for 180 days. Magnitudes of estimated effects on physical activity and sleeping problems remain uncertain.
冠状病毒感染（SARS-CoV-2）是否会影响老年人的体力活动、睡眠问题、体重、社交隔离感和生活质量（QoL）存在争议。我们调查了感染后 180 天内，感染冠状病毒的老年人和未感染冠状病毒的老年人在这些结果上的差异。
我们纳入了 Lifelines COVID-19 队列研究中的 6789 名老年人（65 岁以上），他们在 2020 年 4 月至 2021 年 6 月期间提供了数据。在性别、年龄、教育、居住状况、体重指数、吸烟状况、脆弱健康状况、感染时间和感染前健康状况方面，对感染冠状病毒的老年人和未感染冠状病毒的老年人进行了匹配。使用加权线性混合模型，调整了政府政策措施的严格程度，比较了两组感染后的健康结果。
共有 309 名参与者冠状病毒检测呈阳性。感染后 8 天，感染冠状病毒的老年人的体力活动减少，睡眠问题更多，体重减轻，社交隔离感更强，生活质量更低。90 天后，体重、社交隔离感和生活质量的差异消失。然而，感染后 90 天仍存在体力活动的差异，感染后 180 天仍存在睡眠问题。
我们的研究结果发现，冠状病毒感染与所有检查结果均呈负相关，体力活动的相关性持续 90 天，睡眠问题的相关性持续 180 天。体力活动和睡眠问题的估计影响的幅度仍不确定。
