Mondy Vimal Chacko, Peter S Babu, Ravi R
Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India.
Indian J Radiol Imaging. 2020 Oct-Dec;30(4):465-472. doi: 10.4103/ijri.IJRI_326_20. Epub 2021 Jan 13.
Newer cardiac magnetic resonance techniques like native T1 mapping are being used increasingly as an adjunct to diagnose myocardial diseases with fibrosis. However, its full clinical utility has not been tested extensively, especially in the Indian population. The purpose of this study was to find native T1 values in healthy individuals without cardiac disease in our 3-Tesla MRI system and examine whether native myocardial T1 values can be used to differentiate between normal and diffuse myocardial disease groups.
After approval from the institutional ethics committee, native T1 mapping was performed in 12 healthy individuals without cardiac disease who served as controls and in 26 patients with diffuse myocardial diseases (acute myocarditis ( = 5), hypertrophic cardiomyopathy (HCM) ( = 8), nonischemic dilated cardiomyopathy (DCM) ( = 7), restrictive cardiomyopathy (RCM) due to amyloidosis ( = 6)) in a 3-Tesla MRI system in short axis slices and four-chamber view using a modified Look-Locker inversion recovery sequence. The mean native T1 values and standard deviations were calculated for control and disease groups and compared. The ability of native myocardial T1 mapping to differentiate between normal and diffuse myocardial disease groups was assessed. One-way ANOVA with Tukey's Post-Hoc test was used to find significant difference in the multivariate analysis and Chi-Square test was used to find the significance in categorical data.
The native T1 values for the healthy group in our 3-Tesla MRI system was 1186.47 ± 45.67 ms. The mean T1 values of the groups acute myocarditis (1418.68 ± 8.62 ms), HCM (1355.86 ± 44.67 ms), nonischemic DCM (1341.31 ± 41.48 ms), and RCM due to amyloidosis (1370.37 ± 90.14 ms) were significantly higher ( = 0.0005) than that of the healthy control group.
Native myocardial T1 mapping is a promising tool for differentiating between healthy and diffuse myocardial disease groups.
像天然T1映射这样更新的心脏磁共振技术越来越多地被用作诊断伴有纤维化的心肌疾病的辅助手段。然而，其完整的临床效用尚未得到广泛测试，尤其是在印度人群中。本研究的目的是在我们的3特斯拉磁共振成像系统中找出无心脏病的健康个体的天然T1值，并检查天然心肌T1值是否可用于区分正常和弥漫性心肌疾病组。
经机构伦理委员会批准后，在12名无心脏病的健康个体（作为对照组）以及26名患有弥漫性心肌疾病的患者（急性心肌炎（n = 5）、肥厚型心肌病（HCM）（n = 8）、非缺血性扩张型心肌病（DCM）（n = 7）、淀粉样变性所致限制性心肌病（RCM）（n = 6））中，使用改良的Look-Locker反转恢复序列在3特斯拉磁共振成像系统的短轴切片和四腔视图中进行天然T1映射。计算对照组和疾病组的平均天然T1值及标准差并进行比较。评估天然心肌T1映射区分正常和弥漫性心肌疾病组的能力。在多变量分析中使用带有Tukey事后检验的单因素方差分析来发现显著差异，使用卡方检验来发现分类数据中的显著性。
我们的3特斯拉磁共振成像系统中健康组的天然T1值为1186.47 ± 45.67毫秒。急性心肌炎组（1418.68 ± 8.62毫秒）、HCM组（1355.86 ± 44.67毫秒）、非缺血性DCM组（1341.31 ± 41.48毫秒）以及淀粉样变性所致RCM组（1370.37 ± 90.14毫秒）的平均T1值显著高于健康对照组（P = 0.0005）。
天然心肌T1映射是区分健康和弥漫性心肌疾病组的一种有前景的工具。
