Luu Doan Tien, Duc Nguyen Minh, My Thieu-Thi Tra, Giang Tran-Van, Bang Luong Viet, Lenh Bui-Van
Department of Radiology, Ha Noi Medical University Hospital, Ha Noi, Vietnam.
Department of Radiology, Ha Noi Medical University, Ha Noi, Vietnam.
World J Oncol. 2021 Feb;12(1):39-43. doi: 10.14740/wjon1356. Epub 2021 Feb 10.
Gestational choriocarcinoma (GC) is an uncommon malignant tumor consisting of trophoblastic cells. The lungs, liver, and central nervous system are the most common metastatic sites for this disease. However, splenic metastasis is unusual and might result in spontaneous rupture. Symptoms associated with splenic rupture may be the first presentation of malignancy. A thorough medical history and examination are necessary to detect the primary lesion. Herein, we present a case of a 23-year-old female who had splenic rupture secondary to choriocarcinoma metastasis. Although the emergency condition had been solved, the patient died 1 month after due to brain metastasis. The goal of this article was to report a new case of spontaneous splenic rupture caused by choriocarcinoma metastasis and to review the existing literature on splenic metastases associated with GC, including the epidemiology and etiology.
妊娠滋养细胞肿瘤（GC）是一种由滋养层细胞组成的罕见恶性肿瘤。肺、肝和中枢神经系统是该疾病最常见的转移部位。然而，脾转移并不常见，可能导致自发性破裂。与脾破裂相关的症状可能是恶性肿瘤的首发表现。详细的病史和检查对于发现原发病变是必要的。在此，我们报告一例23岁女性因绒毛膜癌转移导致脾破裂的病例。尽管紧急情况已得到解决，但患者在1个月后因脑转移死亡。本文的目的是报告一例由绒毛膜癌转移引起的自发性脾破裂新病例，并回顾现有的关于与妊娠滋养细胞肿瘤相关的脾转移的文献，包括流行病学和病因学。
