Khalil Ahmadaye Ibrahim, Bendahhou Karima, Mestaghanmi Houriya, Saile Rachid, Benider Abdellatif
Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Maroc.
Registre des Cancers de la Région du Grand Casablanca, Maroc.
Pan Afr Med J. 2016 Oct 6;25:74. doi: 10.11604/pamj.2016.25.74.9966. eCollection 2016.
Breast cancer is most common in women and it is among the leading causes of cancer related deaths. The curability of this type of tumor is increasing thanks to screening programs and treatment advances which have certainly enhanced patient survival. But challenges remain, particularly in respect of phenotypic instability of cancer cells. The aim of this study was to analyse the phenotypic profile of breast cancer in patients treated at Mohammed VI Cancer Treatment Center over the years 2013-2014. We conducted a cross-sectional study over a two-year period, including the cases of breast cancer treated in our Center. Data were collected from patients medical records and analyzed using Epi Info software. 1277 patients were treated in our Center. 99.5% were females, mean age 50.20 ± 11.34 years. The most common histological type was invasive ductal carcinoma (80.7% of cases). It was diagnosed at an early stage (56,9%). The most common molecular phenotype was luminal A (41.4% of cases). Luminal B, HER2 and triple negatives occurred in 10.4%, 6.3%, 11.2% of cases respectively. The study of tumor phenotype in patients with breast cancer helps clinician make treatment choice and policy makers implement programs against this disease.
乳腺癌在女性中最为常见，是癌症相关死亡的主要原因之一。由于筛查项目和治疗进展，这种类型肿瘤的治愈率正在提高，这无疑提高了患者的生存率。但挑战依然存在，尤其是癌细胞的表型不稳定性方面。本研究的目的是分析2013年至2014年在穆罕默德六世癌症治疗中心接受治疗的乳腺癌患者的表型特征。我们在两年期间进行了一项横断面研究，纳入了在我们中心接受治疗的乳腺癌病例。数据从患者病历中收集，并使用Epi Info软件进行分析。我们中心共治疗了1277例患者。其中99.5%为女性，平均年龄50.20±11.34岁。最常见的组织学类型是浸润性导管癌（占病例的80.7%）。其在早期被诊断出来（占56.9%）。最常见的分子表型是管腔A型（占病例的41.4%）。管腔B型、HER2型和三阴性分别占病例的10.4%、6.3%、11.2%。对乳腺癌患者肿瘤表型的研究有助于临床医生做出治疗选择，也有助于政策制定者实施针对这种疾病的项目。
