Laboratory for Experimental Orthopedics Department of Orthopedic Surgery Maastricht University Medical Center Maastricht The Netherlands.
Laboratory Animal Facility Maastricht University Maastricht The Netherlands.
Animal Model Exp Med. 2021 Feb 10;4(1):54-58. doi: 10.1002/ame2.12150. eCollection 2021 Mar.
Goats or sheep are the preferred animal model for the preclinical evaluation of cartilage repair techniques due to the similarity of the goat stifle joint to the human knee. The medial femoral condyle of the stifle joint is the preferred site for the assessment of articular cartilage repair, as this is the primary location for this type of lesion in the human knee. Proper surgical exposure of the medial femoral condyle is paramount to obtain reproducible results without surgical error. When applying the standard human medial arthrotomy technique on the goat stifle joint, there are some key aspects to consider in order to prevent destabilization of the extensor apparatus and subsequent postoperative patellar dislocations with associated animal discomfort. This paper describes a modified surgical technique to approach the medial femoral condyle of the caprine stifle joint. The modified technique led to satisfactory exposure without postoperative incidence of patellar luxations and no long-term adverse effects on the joint.
由于山羊膝关节与人类膝关节相似，因此山羊或绵羊是用于软骨修复技术临床前评估的首选动物模型。膝关节的股骨内髁是评估关节软骨修复的首选部位，因为这是人类膝关节中这种类型损伤的主要部位。为了获得无手术错误的可重复结果，正确地进行股骨内髁的外科暴露至关重要。当在山羊膝关节上应用标准的人类内侧关节切开术技术时，需要考虑一些关键方面，以防止伸肌装置不稳定以及随后的术后髌骨脱位，以及随之而来的动物不适。本文描述了一种改良的手术技术，用于接近山羊膝关节的股骨内髁。改良后的技术可实现满意的暴露，术后无髌骨脱位发生，对关节也没有长期不良影响。
