Sorbonne Paris Nord University/INSERM/INRAE/CNAM, Nutritional Epidemiology Research Group (EREN), Epidemiology and Statistics Research Center, University of Paris, 74 rue Marcel Cachin, 93017, Bobigny, France.
Department of Public Health, AP-HP Paris Seine-Saint-Denis University Hospital System, Bobigny, France.
Eur J Nutr. 2021 Oct;60(7):3669-3678. doi: 10.1007/s00394-021-02531-1. Epub 2021 Mar 18.
We investigated the association between the inflammatory potential of the diet and hearing loss in the context of aging.
We studied 3435 French adults enrolled in the SU.VI.MAX 2 (2007-2009) cohort. The inflammatory potential of the diet was estimated by the Dietary Inflammatory Index (DII) using ≥ 3 baseline 24-h dietary records. Subjective hearing loss was assessed after a mean of 12.5 ± 0.7 years by 3 individual items (ability to carry a conversation in a noisy setting, frequently asking for repetition, and need to increase the television/radio volume) and by a composite score, dichotomized for analyses. We fit sex-specific multivariable logistic regression models.
Compared with males, females had higher DII scores (i.e., more pro-inflammatory diet) and less subjective hearing loss. Among males, a significant positive association between DII (continuous scale) and inability to carry a conversation in a noisy setting was found (OR = 1.10; 95% CI 1.02, 1.18), while the opposite was seen among females (OR = 0.92; 95% CI 0.87, 0.98). Regarding the need to turn up the television/radio volume, a significant positive association with DII (continuous scale) was found only among males (OR = 1.09; 95% CI 1.01, 1.18). A significant association with the subjective hearing loss composite score was found among females (OR = 0.74; 95% CI 0.57, 0.97).
The findings among males supported the hypothesis that a pro-inflammatory diet could increase risk of hearing loss, whereas the findings among females were unexpected. This study could provide impetus for future research in sensory disability and aging.
www.clinicaltrials.gov # NCT00272428.
我们研究了饮食的炎症潜能与衰老背景下听力损失之间的关系。
我们研究了参加 SU.VI.MAX 2（2007-2009 年）队列的 3435 名法国成年人。通过使用≥3 份基线 24 小时膳食记录，采用膳食炎症指数（DII）来评估饮食的炎症潜能。在平均 12.5±0.7 年后，通过 3 个独立项目（在嘈杂环境中进行对话的能力、经常要求重复以及需要增加电视/收音机音量）和复合评分来评估主观听力损失，并进行分析。我们拟合了性别特异性多变量逻辑回归模型。
与男性相比，女性的 DII 评分更高（即更具促炎作用的饮食），主观听力损失较少。在男性中，DII（连续量表）与在嘈杂环境中无法进行对话之间存在显著正相关（OR=1.10；95%CI，1.02，1.18），而在女性中则相反（OR=0.92；95%CI，0.87，0.98）。对于需要调高电视/收音机音量，仅在男性中，DII（连续量表）与该需求之间存在显著正相关（OR=1.09；95%CI，1.01，1.18）。在女性中，与主观听力损失综合评分存在显著相关性（OR=0.74；95%CI，0.57，0.97）。
男性的研究结果支持了促炎饮食可能增加听力损失风险的假设，而女性的研究结果则出人意料。本研究为未来有关感官障碍和衰老的研究提供了动力。
www.clinicaltrials.gov # NCT00272428。
