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透明质酸酯治疗慢性难愈合伤口:6例患者的病例系列

[Treatment of chronic hard-to-heal wounds with hyaloronic acid ester: a case series of six patients].

作者信息

Maitz Emanuel, Binder Barbara

机构信息

Univ.-Klinik für Orthopädie und Traumatologie, Medizinische Universität Graz, Auenbruggerplatz 5, 8036, Graz, Österreich.

Univ.-Klinik für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.

出版信息

Wien Med Wochenschr. 2022 Feb;172(1-2):52-56. doi: 10.1007/s10354-021-00831-z. Epub 2021 Mar 18.

DOI:10.1007/s10354-021-00831-z
PMID:33738631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8837515/
Abstract

The treatment of chronic wounds is usually a major challenge for the involved medical staff. Various different treatment options have to be tested achieving a satisfactory result. In this retrospective case report, we describe successful treatments with hyaluronan acid ester fleece in six patients with chronic wounds of different origins. Furthermore, all patients received compression bandages or compression stockings, two patients were treated additionally with pressure relief devices and all were debrided if necessary. The chronic wounds of five out of the six patients healed completely over a period of 1.5-11 months or only with a minimal residual defect. However, one patient was still resistant to therapy over five months. In summary, the treatment with hyaluronan esters achieved good results especially in patients with complex medical history that makes a successful therapy particularly difficult.

摘要

慢性伤口的治疗通常对相关医护人员来说是一项重大挑战。必须尝试各种不同的治疗方案以取得满意的效果。在这份回顾性病例报告中,我们描述了6例不同病因的慢性伤口患者使用透明质酸酯纤维敷料成功治疗的情况。此外,所有患者均接受了加压绷带或加压弹力袜治疗,2例患者还额外接受了减压装置治疗,所有患者必要时均进行了清创。6例患者中有5例的慢性伤口在1.5至11个月的时间内完全愈合,或仅留下极小的残余缺损。然而,有1例患者在5个月以上的时间里仍对治疗有抵抗。总之,透明质酸酯治疗取得了良好效果,尤其是对于那些病史复杂、成功治疗特别困难的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/06a7c0ef7f2d/10354_2021_831_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/1ebfda263dec/10354_2021_831_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/d85e82a3436d/10354_2021_831_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/0f7c35d642d7/10354_2021_831_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/06a7c0ef7f2d/10354_2021_831_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/1ebfda263dec/10354_2021_831_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/d85e82a3436d/10354_2021_831_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/0f7c35d642d7/10354_2021_831_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d184/8837515/06a7c0ef7f2d/10354_2021_831_Fig4_HTML.jpg

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Wien Med Wochenschr. 2022 Feb;172(1-2):52-56. doi: 10.1007/s10354-021-00831-z. Epub 2021 Mar 18.
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本文引用的文献

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Hyaluronic Acid Accelerates Re-epithelialization and Alters Protein Expression in a Human Wound Model.透明质酸在人体伤口模型中加速上皮再形成并改变蛋白质表达。
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Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory.透明质酸:分子机制与治疗进展
Front Vet Sci. 2019 Jun 25;6:192. doi: 10.3389/fvets.2019.00192. eCollection 2019.
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Hyaluronic Acid in the Third Millennium.第三个千年的透明质酸。
Polymers (Basel). 2018 Jun 25;10(7):701. doi: 10.3390/polym10070701.
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Emerging evidence for the essential role of hyaluronan in cutaneous biology.越来越多的证据表明透明质酸在皮肤生物学中起着重要作用。
J Dermatol Sci. 2019 Apr;94(1):190-195. doi: 10.1016/j.jdermsci.2019.01.009. Epub 2019 Mar 19.
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Development and use of biomaterials as wound healing therapies.生物材料作为伤口愈合疗法的开发与应用。
Burns Trauma. 2019 Jan 25;7:2. doi: 10.1186/s41038-018-0139-7. eCollection 2019.
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Epidemiology of chronic wounds in Germany: Analysis of statutory health insurance data.德国慢性伤口的流行病学:法定医疗保险数据分析
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Hyaluronic acid and wound healing.透明质酸与伤口愈合。
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Hyaluronan in wound healing: rediscovering a major player.透明质酸在伤口愈合中的作用:重新认识一个重要角色。
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9
Hyaluronan fragments improve wound healing on in vitro cutaneous model through P2X7 purinoreceptor basal activation: role of molecular weight.透明质酸片段通过 P2X7 嘌呤能受体的基础激活促进体外皮肤模型的伤口愈合:分子量的作用。
PLoS One. 2012;7(11):e48351. doi: 10.1371/journal.pone.0048351. Epub 2012 Nov 16.
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Cost-of-illness of leg ulcers in the community.社区中腿部溃疡的疾病成本。
Int Wound J. 2014 Jun;11(3):283-92. doi: 10.1111/j.1742-481X.2012.01089.x. Epub 2012 Oct 1.