Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, India.
Centre for Biotechnology, Anna University, Chennai, 600 025, India.
Mol Cell Biochem. 2021 Jul;476(7):2857-2867. doi: 10.1007/s11010-021-04116-2. Epub 2021 Mar 18.
Global influence of male infertility is increasing in recent decades. Proper understanding of genetics, anatomy, physiology and the intricate interrelation of male reproductive system are much needed for explaining the etiology of male infertility; and a detailed study on the epigenetics, indeed, will reveal the molecular mechanism behind its etiology. Sirtuins, the molecular sensors, are NAD dependent histone deacetylases and ADP- ribosyl transferases, participate in the chief events of epigenetics. In mammals, sirtuin family comprises seven members (SIRT1-SIRT7), and they all possess a conserved NAD binding catalytic domain, termed the sirtuin core domain which is imperative for their activity. Sirtuins exert a pivotal role in cellular homeostasis, energy metabolism, apoptosis, age-related disorders and male reproductive system. However, their exact role in male reproduction is still obscure. This article specifically reviews the role of mammalian sirtuins in male reproductive function, thereby, prompting further research to discover the restorative methods and its implementation in reproductive medicine.
近几十年来，男性不育症的全球影响力正在增加。为了解释男性不育症的病因，人们非常需要正确理解遗传学、解剖学、生理学以及男性生殖系统的复杂相互关系；对表观遗传学进行详细研究确实可以揭示其病因的分子机制。Sirtuins 是一种分子传感器，是 NAD 依赖性组蛋白去乙酰化酶和 ADP-核糖基转移酶，参与表观遗传学的主要事件。在哺乳动物中，Sirtuin 家族由七个成员（SIRT1-SIRT7）组成，它们都具有保守的 NAD 结合催化结构域，称为 Sirtuin 核心结构域，这对其活性至关重要。Sirtuins 在细胞内稳态、能量代谢、细胞凋亡、与年龄相关的疾病和男性生殖系统中发挥着关键作用。然而，它们在男性生殖中的确切作用仍不清楚。本文专门综述了哺乳动物 Sirtuins 在男性生殖功能中的作用，从而促使进一步研究发现恢复方法及其在生殖医学中的应用。
