Wang Jiaqi, Zhang Yi, Liu Lianyu, Yang Ting, Song Jun
Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
Institute of Digestive Diseases of Xuzhou Medical University, Xuzhou 221002, China.
Cancer Biol Med. 2021 Mar 19;18(2):421-36. doi: 10.20892/j.issn.2095-3941.2020.0312.
Chemotherapeutics are validated conventional treatments for patients with advanced cancer. However, with continual application of chemotherapeutics, chemoresistance, which is often predictive of poor prognosis, has gradually become a concern in recent years. Circular RNAs (circRNAs), a class of endogenous noncoding RNAs (ncRNAs) with a closed-loop structure, have been reported to be notable targets and markers for the prognosis, diagnosis, and treatment of many diseases, particularly cancer. Although dozens of studies have shown that circRNAs play major roles in drug-resistance activity in tumors, the mechanisms by which circRNAs affect chemoresistance have yet to be explored. In this review, we describe the detailed mechanisms of circRNAs and chemotherapeutics in various cancers and summarize potential therapeutic targets for drug-resistant tumors.
化疗药物是晚期癌症患者经证实有效的传统治疗方法。然而，随着化疗药物的持续应用，化疗耐药性近年来逐渐成为一个问题，而化疗耐药性往往预示着预后不良。环状RNA（circRNAs）是一类具有闭环结构的内源性非编码RNA（ncRNAs），据报道，它们是许多疾病，尤其是癌症的预后、诊断和治疗的重要靶点和标志物。尽管数十项研究表明circRNAs在肿瘤的耐药活性中起主要作用，但circRNAs影响化疗耐药性的机制尚待探索。在本综述中，我们描述了circRNAs和化疗药物在各种癌症中的详细机制，并总结了耐药肿瘤的潜在治疗靶点。
