Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain.
Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain.
Crit Rev Food Sci Nutr. 2022;62(23):6293-6314. doi: 10.1080/10408398.2021.1900058. Epub 2021 Mar 19.
Colon cancer is the fourth leading cause of cancer deaths around the world. Despite advances in understanding its etiology and in diagnosis and treatment, new therapeutic strategies are still required. In this sense, the and families have been widely used to treat various pathologies, including cancer, for their bioactive components. The objective of this systematic review was to analyze the antitumor activity of the bioactive components present in extracts from and families using different in in vitro models of colon cancer. 241 publications have been identified (published from January 2008 to January 2020) from different electronic data base. 44 articles were included, 26 of which examined the Solanaceae family. The antitumor activity exhibited by this family was due to the withanolide-type steroid compounds they harbor. 18 articles were related to the Cucurbitaceae family. This family is characterized by their production of cucurbitacin-type triterpenoid compounds and their derivatives, which confer antitumor activity. In conclusion, the different genera belonging to both families are an important source of bioactive compounds with relevant activity against colon cancer. More experimental and in vivo studies will be required to corroborate their antitumor activity and to leverage them in future clinical practice.
结直肠癌是全球癌症死亡的第四大主要原因。尽管在了解其病因、诊断和治疗方面取得了进展，但仍需要新的治疗策略。在这方面，茄科和葫芦科植物因其生物活性成分已被广泛用于治疗各种疾病，包括癌症。本系统评价的目的是分析从茄科和葫芦科植物提取物中分离出的生物活性成分在体外结肠癌模型中的抗肿瘤活性。从不同的电子数据库中确定了 241 篇出版物（发表于 2008 年 1 月至 2020 年 1 月）。共纳入 44 篇文章，其中 26 篇研究了茄科植物。该家族的抗肿瘤活性归因于其所含的茄啶型甾体化合物。与葫芦科有关的文章有 18 篇。该科的特点是产生葫芦素型三萜类化合物及其衍生物，具有抗肿瘤活性。总之，这两个科的不同属是具有对抗结肠癌相关活性的生物活性化合物的重要来源。需要更多的实验和体内研究来证实它们的抗肿瘤活性，并在未来的临床实践中加以利用。
