Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Research Department, Moy-Fincher-Chipps Facial Plastics and Dermatology, Beverly Hills, CA, 90210, USA.
Int J Dermatol. 2021 Dec;60(12):1481-1487. doi: 10.1111/ijd.15541. Epub 2021 Mar 19.
Hormone replacement therapy and various devices exist to treat signs of aging, such as skin thinning, yet there are no reviews summarizing or evaluating their role in neocollagenesis and the associated increase in skin thickness.
To review the literature regarding stimulation and generation of new collagen in the dermis in two parts. Part 2 reviews oral and topical hormone replacement therapy as well as energy-based devices.
The PubMed database was searched for related literature. Studies involving the use of hormone supplements and energy devices with a resultant change in collagen production or skin thickness were obtained and reviewed for evidence.
Hormones, including estrogen, testosterone, and dehydroepiandrosterone, and human growth hormone have been reported with substantiating evidence for neocollagenesis and dermal thickening. Energy devices, including radiofrequency, ultrasound, and laser therapy, have also been reported to stimulate neocollagenesis.
The results presented in certain literature are not based on randomized controlled trials.
Hormone deficient individuals can regain skin thickness with hormone replacement therapy. Dermal heating can provide a substantial amount of neocollagenesis; however, laser technology, specifically CO , appears to be the most effective at increasing skin collagen and tightening.
有激素替代疗法和各种设备可用于治疗衰老迹象，如皮肤变薄，但没有综述总结或评估它们在新胶原形成和相关的皮肤厚度增加中的作用。
分两部分综述真皮中胶原刺激和生成的文献。第 2 部分综述口服和局部激素替代疗法以及基于能量的设备。
在 PubMed 数据库中搜索相关文献。获取并回顾了涉及使用激素补充剂和能量设备且胶原生成或皮肤厚度有变化的研究，以获取证据。
有充分证据表明，激素（包括雌激素、睾酮和脱氢表雄酮）和人生长激素可促进新胶原形成和真皮增厚。射频、超声和激光疗法等能量设备也被报道可刺激新胶原形成。
某些文献中的结果并非基于随机对照试验。
激素缺乏的个体可以通过激素替代疗法恢复皮肤厚度。真皮加热可提供大量的新胶原形成；然而，激光技术，特别是 CO 2，似乎是增加皮肤胶原蛋白和紧致度最有效的方法。
