Grupo Fleury, São Paulo, SP, Brasil,
Grupo Fleury, São Paulo, SP, Brasil.
Arch Endocrinol Metab. 2021 Nov 3;65(3):381-385. doi: 10.20945/2359-3997000000343. Epub 2021 Mar 19.
In recent years the immunomodulatory actions of vitamin D, a steroid hormone, have been extensively studied. In 2020, due to the COVID-19 pandemic, the question arose as to 25(OH)D status would be related to susceptibility to SARS-CoV-2 infection, since several studies pointed out a higher prevalence and severity of the disease in populations with low levels of 25(OH)D. Thus, we investigated the 25(OH)D levels in adults "Detected" positive for SARS CoV-2 by RT-PCR (reverse transcriptase polymerase chain reaction) test, and in negative controls, "not Detected", using the Fleury Group's examination database, in Sao Paulo, Brazil. Of a total of 14.692 people with recent assessments of 25(OH)D and RT-PCR tests for COVID-19, 2.345 were positive and 11.585 were negative for the infection. The groups did not differ in the percentage of men and women, or in the age distribution. There were no differences in the distribution of 25(OH)D between the two groups (p = 0.08); mean 25(OH)D of 28.8 ± 21.4 ng/mL and 29.6 ± 18.1 ng/mL, respectively. In the specific population studied, clinical, environmental, socioeconomic and cultural factors should have greater relevance than 25(OH)D in determining the susceptibility to COVID-19.
近年来，维生素 D（一种类固醇激素）的免疫调节作用受到了广泛的研究。2020 年，由于 COVID-19 大流行，人们开始研究 25(OH)D 状态是否与 SARS-CoV-2 感染易感性有关，因为几项研究指出，25(OH)D 水平较低的人群中，该疾病的患病率和严重程度更高。因此，我们利用巴西圣保罗 Fleury 集团的检查数据库，调查了 RT-PCR（逆转录聚合酶链反应）检测 SARS CoV-2 阳性的成年人（“检测出”阳性）和阴性对照者（“未检测出”）的 25(OH)D 水平。在总共 14692 名最近接受过 25(OH)D 评估和 COVID-19 RT-PCR 检测的人群中，2345 人检测结果为阳性，11585 人检测结果为阴性。两组在男女比例和年龄分布上没有差异。两组间 25(OH)D 的分布没有差异（p = 0.08）；阳性组的平均 25(OH)D 为 28.8 ± 21.4ng/ml，阴性组为 29.6 ± 18.1ng/ml。在研究的特定人群中，临床、环境、社会经济和文化因素对确定 COVID-19 的易感性可能比 25(OH)D 更重要。
