Department of Hepatopancreatobiliary Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cell Death Dis. 2021 Mar 19;12(4):300. doi: 10.1038/s41419-021-03585-z.
The innate and adaptive immune cells have complex signaling pathways for sensing and initiating immune responses against disease. These pathways are interrupted at different levels to occur immune evasion, including by N6-methyladenosine (m6A) modification. In this review, we discuss studies revealing the immune evasion mechanism by m6A modification, which underlies the retouching of these signaling networks and the rapid tolerance of innate and adaptive immune molecules during disease. We also focus on the functions of m6A in main chemokines regulation, and their roles in promotive and suppressive immune cell recruitment. We then discuss some of the current challenges in the field and describe future directions for the immunological mechanisms of m6A modification.
先天免疫和适应性免疫细胞具有复杂的信号通路，用于感知和启动针对疾病的免疫反应。这些通路在不同水平上被中断，以发生免疫逃逸，包括通过 N6-甲基腺苷（m6A）修饰。在这篇综述中，我们讨论了揭示 m6A 修饰的免疫逃逸机制的研究，该机制是这些信号网络的修饰以及先天和适应性免疫分子在疾病过程中快速耐受的基础。我们还重点讨论了 m6A 在主要趋化因子调节中的功能，以及它们在促进和抑制免疫细胞募集中的作用。然后，我们讨论了该领域的一些当前挑战，并描述了 m6A 修饰的免疫机制的未来方向。
