Department of Otolaryngology Surgery, Beilun District People's Hospital, Ningbo, Zhejiang, China.
J Chin Med Assoc. 2021 May 1;84(5):498-503. doi: 10.1097/JCMA.0000000000000523.
Low diagnostic efficiency and high metastasis and recurrence of nasopharyngeal carcinoma (NPC) result in bad survival. A novel diagnostic biomarker is of great importance for the improvement of NPC management. This study aimed to state the biological function and diagnostic values of miR-762 in NPC to provide a novel insight into the detection and therapy of NPC.
The expression of miR-762 in NPC and healthy samples was detected by quantitative real-time polymerase chain reaction and its diagnostic value was evaluated by the receiver operating characteristic (ROC) analysis. The functional roles of miR-762 in the proliferation, migration, and invasion of NPC cells were assessed by CCK8 and Transwell assay.
The significant upregulation of miR-762 was observed in NPC serum compared with healthy controls, which was associated with the TNM stage and lymph node metastasis of NPC patients. The ROC curve showed that miR-762 could be a diagnostic biomarker for NPC with high accuracy and specificity. Additionally, miR-762 served as a tumor promoter, which could promote cell proliferation, migration, and invasion of NPC.
The upregulation of miR-762 in NPC is associated with the disease progression and diagnosis of NPC. miR-762 might be involved in the tumor progression of NPC, which provides a potential therapeutic target for the treatment and management of NPC.
鼻咽癌（NPC）的诊断效率低，转移和复发率高，导致生存状况不佳。新型诊断生物标志物对于改善 NPC 管理具有重要意义。本研究旨在阐述 miR-762 在 NPC 中的生物学功能和诊断价值，为 NPC 的检测和治疗提供新的思路。
通过实时定量聚合酶链反应检测 NPC 和健康样本中 miR-762 的表达，并通过接受者操作特征（ROC）分析评估其诊断价值。通过 CCK8 和 Transwell 测定评估 miR-762 对 NPC 细胞增殖、迁移和侵袭的功能作用。
与健康对照组相比，NPC 血清中 miR-762 的表达显著上调，与 NPC 患者的 TNM 分期和淋巴结转移有关。ROC 曲线表明，miR-762 可作为 NPC 的高准确性和特异性诊断生物标志物。此外，miR-762 作为一种肿瘤促进物，可促进 NPC 细胞的增殖、迁移和侵袭。
miR-762 在 NPC 中的上调与疾病进展和 NPC 的诊断有关。miR-762 可能参与 NPC 的肿瘤进展，为 NPC 的治疗和管理提供了潜在的治疗靶点。
